A phosphoramidite-based synthesis of phosphoramidate amino acid diesters of antiviral nucleosides

Timothy W. Abraham, Carston R. Wagner

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

A general synthetic procedure is presented for the preparation of 5’-amino acid phosphoramidates of zidovudine (AZT), 3’-deoxy-2’,3’-didehydro-thymidine (D4T), and 3'-fluoro-3’-deoxythymidine (FLT) from their corresponding phosphoramidites. These water soluble amino acid phosphoramidates are more non-polar than the parent nucleoside and exhibit high stability in aqueous media.

Original languageEnglish (US)
Pages (from-to)1891-1903
Number of pages13
JournalNucleosides and Nucleotides
Volume13
Issue number9
DOIs
StatePublished - Sep 1 1994

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Nucleosides
Antiviral Agents
Stavudine
Amino Acids
Zidovudine
Thymidine
Water
phosphoramidite
phosphoramidic acid
alovudine

Cite this

A phosphoramidite-based synthesis of phosphoramidate amino acid diesters of antiviral nucleosides. / Abraham, Timothy W.; Wagner, Carston R.

In: Nucleosides and Nucleotides, Vol. 13, No. 9, 01.09.1994, p. 1891-1903.

Research output: Contribution to journalArticle

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