A phase II trial of human recombinant lnterleukin‐2 administered as a 4‐day continuous infusion for children with refractory neuroblastoma, non‐Hodgkin's lymphoma, sarcoma, renal cell carcinoma, and malignant melanoma. A childrens cancer group study

Madeline Bauer; Gregory H. Reaman; Jacquelyn A. Hank; Mitchell S. Cairo; Peter Anderson; Bruce R. Blazar; Sharon Frierdich; Paul M. Sondel

doi:10.1002/1097-0142(19950615)75:12<2959::AID-CNCR2820751225>3.0.CO;2-R

A phase II trial of human recombinant lnterleukin‐2 administered as a 4‐day continuous infusion for children with refractory neuroblastoma, non‐Hodgkin's lymphoma, sarcoma, renal cell carcinoma, and malignant melanoma. A childrens cancer group study

Madeline Bauer
, Gregory H. Reaman
, Jacquelyn A. Hank
, Mitchell S. Cairo
, Peter Anderson
, Bruce R. Blazar
, Sharon Frierdich
, Paul M. Sondel

Health Sciences Administration

Research output: Contribution to journal › Article › peer-review

55 Scopus citations

Abstract

Background. Recombinant human Interleukin‐2 (IL‐2) has been effective at inducing measurable antitumor responses in adults with renal cell carcinoma and melanoma. It also is being tested as adjuvant therapy for patients with acute myeloid leukemia after autologous bone marrow transplantation. Methods. The authors tested IL‐2 in a pediatric Phase II trial using a regimen that has antitumor effects in adults and was proven to be tolerated acceptably in a prior Phase I pediatric trial. Thirty‐eight patients were entered into this study of whom 36 received IL–2 and were evaluable (20 with sarcoma, 9 with neuroblastoma, 5.

Original language	English (US)
Pages (from-to)	2959-2965
Number of pages	7
Journal	Cancer
Volume	75
Issue number	12
DOIs	https://doi.org/10.1002/1097-0142(19950615)75:12<2959::AID-CNCR2820751225>3.0.CO;2-R
State	Published - Jun 15 1995

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SDG 3 Good Health and Well-being

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Bauer, M., Reaman, G. H., Hank, J. A., Cairo, M. S., Anderson, P., Blazar, B. R., Frierdich, S., & Sondel, P. M. (1995). A phase II trial of human recombinant lnterleukin‐2 administered as a 4‐day continuous infusion for children with refractory neuroblastoma, non‐Hodgkin's lymphoma, sarcoma, renal cell carcinoma, and malignant melanoma. A childrens cancer group study. Cancer, 75(12), 2959-2965. https://doi.org/10.1002/1097-0142(19950615)75:12<2959::AID-CNCR2820751225>3.0.CO;2-R

A phase II trial of human recombinant lnterleukin‐2 administered as a 4‐day continuous infusion for children with refractory neuroblastoma, non‐Hodgkin's lymphoma, sarcoma, renal cell carcinoma, and malignant melanoma. A childrens cancer group study. / Bauer, Madeline; Reaman, Gregory H.; Hank, Jacquelyn A. et al.
In: Cancer, Vol. 75, No. 12, 15.06.1995, p. 2959-2965.

Research output: Contribution to journal › Article › peer-review

Bauer, M, Reaman, GH, Hank, JA, Cairo, MS, Anderson, P, Blazar, BR, Frierdich, S & Sondel, PM 1995, 'A phase II trial of human recombinant lnterleukin‐2 administered as a 4‐day continuous infusion for children with refractory neuroblastoma, non‐Hodgkin's lymphoma, sarcoma, renal cell carcinoma, and malignant melanoma. A childrens cancer group study', Cancer, vol. 75, no. 12, pp. 2959-2965. https://doi.org/10.1002/1097-0142(19950615)75:12<2959::AID-CNCR2820751225>3.0.CO;2-R

Bauer M, Reaman GH, Hank JA, Cairo MS, Anderson P, Blazar BR et al. A phase II trial of human recombinant lnterleukin‐2 administered as a 4‐day continuous infusion for children with refractory neuroblastoma, non‐Hodgkin's lymphoma, sarcoma, renal cell carcinoma, and malignant melanoma. A childrens cancer group study. Cancer. 1995 Jun 15;75(12):2959-2965. doi: 10.1002/1097-0142(19950615)75:12<2959::AID-CNCR2820751225>3.0.CO;2-R

Bauer, Madeline ; Reaman, Gregory H. ; Hank, Jacquelyn A. et al. / A phase II trial of human recombinant lnterleukin‐2 administered as a 4‐day continuous infusion for children with refractory neuroblastoma, non‐Hodgkin's lymphoma, sarcoma, renal cell carcinoma, and malignant melanoma. A childrens cancer group study. In: Cancer. 1995 ; Vol. 75, No. 12. pp. 2959-2965.

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AU - Reaman, Gregory H.

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A phase II trial of human recombinant lnterleukin‐2 administered as a 4‐day continuous infusion for children with refractory neuroblastoma, non‐Hodgkin's lymphoma, sarcoma, renal cell carcinoma, and malignant melanoma. A childrens cancer group study

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