A phase II study of oxaliplatin and prednisone for patients with relapsed or refractory marginal zone lymphoma: Consortium for Improving Survival of Lymphoma trial

Sung Yong Oh; Won Seog Kim; Jin Seok Kim; Yee Soo Chae; Gyeong Won Lee; Hyeon Seok Eom; Hun Mo Ryoo; Suee Lee; Seok Jin Kim; Dok Hyun Yoon; Jong Ho Won; Junshik Hong; Jinny Park; Sang Min Lee; Jung Yong Hong; Eunkyung Park; Hyo Jung Kim; Deok Hwan Yang; Hyo Jin Kim; Cheolwon Suh

doi:10.3109/10428194.2015.1099650

A phase II study of oxaliplatin and prednisone for patients with relapsed or refractory marginal zone lymphoma: Consortium for Improving Survival of Lymphoma trial

Sung Yong Oh, Won Seog Kim, Jin Seok Kim, Yee Soo Chae, Gyeong Won Lee, Hyeon Seok Eom, Hun Mo Ryoo, Suee Lee, Seok Jin Kim, Dok Hyun Yoon, Jong Ho Won, Junshik Hong, Jinny Park, Sang Min Lee, Jung Yong Hong, Eunkyung Park, Hyo Jung Kim, Deok Hwan Yang, Hyo Jin Kim, Cheolwon Suh

Pediatric Blood & Marrow Transplant & Cellular Therapy

Research output: Contribution to journal › Article › peer-review

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Abstract

Overall, more than 50% of marginal zone lymphoma (MZL) patients experience a relapse within 10 years. This phase II trial was conductedto assess the efficacy and safety of oxaliplatin-prednisone (Ox-P) chemotherapy for patients with relapsed or refractory MZL. Patients received oxaliplatin 130 mg/m² on day 1 and prednisone 100 mg/day on days 1-5 of each cycle. A total of 38 patients were enrolled. The median age of the 34 (16 males, 18 females) evaluated patients was 53 (range = 27-74) years. There were seven complete responses (20.6%) and 15 partial responses (44.1%) (Overall response rate = 64.7%). No treatment-related deaths occurred. The median progression-free survival was 14.2 months (95% CI = 2.1-26.3 months); 3-year overall survival rate was 77.7%. Thus, salvage Ox-P chemotherapy for patients with relapsed or refractory MZL at the stated dosage and schedule showed moderate clinical activity and was considerable in very few selected patients (NCT01068392).

Original language	English (US)
Pages (from-to)	1406-1412
Number of pages	7
Journal	Leukemia and Lymphoma
Volume	57
Issue number	6
DOIs	https://doi.org/10.3109/10428194.2015.1099650
State	Published - Jun 2 2016

Bibliographical note

Publisher Copyright:
© 2015 Taylor & Francis.

Keywords

Oxaliplatin
marginal zone lymphoma
prednisone
refractory
relapse

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Oh, S. Y., Kim, W. S., Kim, J. S., Chae, Y. S., Lee, G. W., Eom, H. S., Ryoo, H. M., Lee, S., Kim, S. J., Yoon, D. H., Won, J. H., Hong, J., Park, J., Lee, S. M., Hong, J. Y., Park, E., Kim, H. J., Yang, D. H., Kim, H. J., & Suh, C. (2016). A phase II study of oxaliplatin and prednisone for patients with relapsed or refractory marginal zone lymphoma: Consortium for Improving Survival of Lymphoma trial. Leukemia and Lymphoma, 57(6), 1406-1412. https://doi.org/10.3109/10428194.2015.1099650

Oh, SY, Kim, WS, Kim, JS, Chae, YS, Lee, GW, Eom, HS, Ryoo, HM, Lee, S, Kim, SJ, Yoon, DH, Won, JH, Hong, J, Park, J, Lee, SM, Hong, JY, Park, E, Kim, HJ, Yang, DH, Kim, HJ & Suh, C 2016, 'A phase II study of oxaliplatin and prednisone for patients with relapsed or refractory marginal zone lymphoma: Consortium for Improving Survival of Lymphoma trial', Leukemia and Lymphoma, vol. 57, no. 6, pp. 1406-1412. https://doi.org/10.3109/10428194.2015.1099650

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title = "A phase II study of oxaliplatin and prednisone for patients with relapsed or refractory marginal zone lymphoma: Consortium for Improving Survival of Lymphoma trial",

abstract = "Overall, more than 50% of marginal zone lymphoma (MZL) patients experience a relapse within 10 years. This phase II trial was conductedto assess the efficacy and safety of oxaliplatin-prednisone (Ox-P) chemotherapy for patients with relapsed or refractory MZL. Patients received oxaliplatin 130 mg/m2 on day 1 and prednisone 100 mg/day on days 1-5 of each cycle. A total of 38 patients were enrolled. The median age of the 34 (16 males, 18 females) evaluated patients was 53 (range = 27-74) years. There were seven complete responses (20.6%) and 15 partial responses (44.1%) (Overall response rate = 64.7%). No treatment-related deaths occurred. The median progression-free survival was 14.2 months (95% CI = 2.1-26.3 months); 3-year overall survival rate was 77.7%. Thus, salvage Ox-P chemotherapy for patients with relapsed or refractory MZL at the stated dosage and schedule showed moderate clinical activity and was considerable in very few selected patients (NCT01068392).",

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doi = "10.3109/10428194.2015.1099650",

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AU - Yoon, Dok Hyun

AU - Won, Jong Ho

AU - Hong, Junshik

AU - Park, Jinny

AU - Lee, Sang Min

AU - Hong, Jung Yong

AU - Park, Eunkyung

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AU - Kim, Hyo Jin

AU - Suh, Cheolwon

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N2 - Overall, more than 50% of marginal zone lymphoma (MZL) patients experience a relapse within 10 years. This phase II trial was conductedto assess the efficacy and safety of oxaliplatin-prednisone (Ox-P) chemotherapy for patients with relapsed or refractory MZL. Patients received oxaliplatin 130 mg/m2 on day 1 and prednisone 100 mg/day on days 1-5 of each cycle. A total of 38 patients were enrolled. The median age of the 34 (16 males, 18 females) evaluated patients was 53 (range = 27-74) years. There were seven complete responses (20.6%) and 15 partial responses (44.1%) (Overall response rate = 64.7%). No treatment-related deaths occurred. The median progression-free survival was 14.2 months (95% CI = 2.1-26.3 months); 3-year overall survival rate was 77.7%. Thus, salvage Ox-P chemotherapy for patients with relapsed or refractory MZL at the stated dosage and schedule showed moderate clinical activity and was considerable in very few selected patients (NCT01068392).

AB - Overall, more than 50% of marginal zone lymphoma (MZL) patients experience a relapse within 10 years. This phase II trial was conductedto assess the efficacy and safety of oxaliplatin-prednisone (Ox-P) chemotherapy for patients with relapsed or refractory MZL. Patients received oxaliplatin 130 mg/m2 on day 1 and prednisone 100 mg/day on days 1-5 of each cycle. A total of 38 patients were enrolled. The median age of the 34 (16 males, 18 females) evaluated patients was 53 (range = 27-74) years. There were seven complete responses (20.6%) and 15 partial responses (44.1%) (Overall response rate = 64.7%). No treatment-related deaths occurred. The median progression-free survival was 14.2 months (95% CI = 2.1-26.3 months); 3-year overall survival rate was 77.7%. Thus, salvage Ox-P chemotherapy for patients with relapsed or refractory MZL at the stated dosage and schedule showed moderate clinical activity and was considerable in very few selected patients (NCT01068392).

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A phase II study of oxaliplatin and prednisone for patients with relapsed or refractory marginal zone lymphoma: Consortium for Improving Survival of Lymphoma trial

Abstract

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Keywords

UN SDGs

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