TY - JOUR
T1 - A phase 2 trial of combination therapy with thalidomide, arsenic trioxide, dexamethasone, and ascorbic acid (TADA) in patients with overlap myelodysplastic/myeloproliferative neoplasms (MDS/MPN) or primary myelofibrosis (PMF)
AU - Bejanyan, Nelli
AU - Tiu, Ramon V.
AU - Raza, Azra
AU - Jankowska, Ania
AU - Kalaycio, Matt
AU - Advani, Anjali
AU - Chan, Josephine
AU - Saunthararajah, Yogen
AU - Mooney, Lindsey
AU - MacIejewski, Jaroslaw P.
AU - Sekeres, Mikkael A.
PY - 2012/8/15
Y1 - 2012/8/15
N2 - BACKGROUND. Primary myelofibrosis (PMF) and overlap myelodysplastic/ myeloproliferative neoplasms (MDS/MPN) are clonal hematopoietic disorders that share similar clinical features and molecular abnormalities, such as the Janus kinase 2 (JAK2) valine to phenylalanine mutation at codon 617 (V617F) and the tet methylcytosine dioxygenase 2 (TET2) mutation. There are limited therapeutic options available for these diseases, and single agents have only modest efficacy. In this phase 2 study, the authors combined multiple active agents (thalidomide, arsenic trioxide, dexamethasone, and ascorbic acid [TADA]) to treat patients with these disorders. METHODS. This multicenter trial was conducted from January 2005 to July 2007. The primary endpoint was to evaluate the efficacy of TADA therapy. Patients received the combination for one 12-week cycle followed by maintenance thalidomide for an additional 3 months. Response was assessed using International Working Group criteria. RESULTS. Among 28 enrolled patients, the median age was 66.5 years; 15 patients had MDS/MPN-unclassifiable, 8 patients had chronic myelomonocytic leukemia type 1, and 5 patients had PMF. Approximately 60% of the patients had normal cytogenetics. The JAK2V617F mutation was detected in 5 of 14 tested patients, and TET2 mutations were detected in 2 of 8 tested patients. Almost half of the patients had splenomegaly. With a median on-study follow-up of 5.7 months, 21 patients (75%) completed the entire 12-week course of therapy, and 6 patients (29%) responded to TADA. With a median extended follow-up of 24.1 months for 15 evaluable patients, the median progression-free survival was 14.4 months, and the median overall survival was 21.4 months. CONCLUSIONS. The TADA regimen yielded clinical responses in patients with PMF and MDS/MPN. To the authors' knowledge, this study represents the first trial targeting this patient population. The results indicated that it is reasonable to incorporate multiple novel agents in the treatment of these rare diseases. Cancer 2012. © 2011 American Cancer Society. The thalidomide, arsenic trioxide, dexamethasone, and ascorbic acid (TADA) regimen yields clinical responses in patients with primary myelofibrosis and myelodysplastic/myeloproliferative neoplasms. It is reasonable to incorporate multiple novel agents in these rare diseases.
AB - BACKGROUND. Primary myelofibrosis (PMF) and overlap myelodysplastic/ myeloproliferative neoplasms (MDS/MPN) are clonal hematopoietic disorders that share similar clinical features and molecular abnormalities, such as the Janus kinase 2 (JAK2) valine to phenylalanine mutation at codon 617 (V617F) and the tet methylcytosine dioxygenase 2 (TET2) mutation. There are limited therapeutic options available for these diseases, and single agents have only modest efficacy. In this phase 2 study, the authors combined multiple active agents (thalidomide, arsenic trioxide, dexamethasone, and ascorbic acid [TADA]) to treat patients with these disorders. METHODS. This multicenter trial was conducted from January 2005 to July 2007. The primary endpoint was to evaluate the efficacy of TADA therapy. Patients received the combination for one 12-week cycle followed by maintenance thalidomide for an additional 3 months. Response was assessed using International Working Group criteria. RESULTS. Among 28 enrolled patients, the median age was 66.5 years; 15 patients had MDS/MPN-unclassifiable, 8 patients had chronic myelomonocytic leukemia type 1, and 5 patients had PMF. Approximately 60% of the patients had normal cytogenetics. The JAK2V617F mutation was detected in 5 of 14 tested patients, and TET2 mutations were detected in 2 of 8 tested patients. Almost half of the patients had splenomegaly. With a median on-study follow-up of 5.7 months, 21 patients (75%) completed the entire 12-week course of therapy, and 6 patients (29%) responded to TADA. With a median extended follow-up of 24.1 months for 15 evaluable patients, the median progression-free survival was 14.4 months, and the median overall survival was 21.4 months. CONCLUSIONS. The TADA regimen yielded clinical responses in patients with PMF and MDS/MPN. To the authors' knowledge, this study represents the first trial targeting this patient population. The results indicated that it is reasonable to incorporate multiple novel agents in the treatment of these rare diseases. Cancer 2012. © 2011 American Cancer Society. The thalidomide, arsenic trioxide, dexamethasone, and ascorbic acid (TADA) regimen yields clinical responses in patients with primary myelofibrosis and myelodysplastic/myeloproliferative neoplasms. It is reasonable to incorporate multiple novel agents in these rare diseases.
KW - and ascorbic acid
KW - arsenic trioxide
KW - dexamethasone
KW - myelodysplastic/myeloproliferative neoplasms
KW - myelofibrosis
KW - primary myelofibrosis
KW - thalidomide
KW - trial
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UR - http://www.scopus.com/inward/citedby.url?scp=84864696330&partnerID=8YFLogxK
U2 - 10.1002/cncr.26741
DO - 10.1002/cncr.26741
M3 - Article
C2 - 22180010
AN - SCOPUS:84864696330
SN - 0008-543X
VL - 118
SP - 3968
EP - 3976
JO - Cancer
JF - Cancer
IS - 16
ER -