A perspective on murine keratinocyte stem cells as targets of chemically induced skin cancer

Thaned Kangsamaksin, Joon Park Heui, Carol S. Trempus, Rebecca J. Morris

Research output: Contribution to journalArticle

40 Scopus citations

Abstract

Although ideas on the stem cell origins of cancer date more than one hundred years, critical evidence to support these theories is largely lacking. Our objective here is to outline our historical perspective on keratinocyte stem cells in the cutaneous epithelium and to summarize specific evidence suggesting that epithelial stem cells may contribute to chemically induced skin cancer. We note that, while strong evidence does support this hypothesis, experiments in progress may provide direct visualization of tumors derived from hair follicle stem cells.

Original languageEnglish (US)
Pages (from-to)579-584
Number of pages6
JournalMolecular Carcinogenesis
Volume46
Issue number8
DOIs
StatePublished - Aug 1 2007
Externally publishedYes

Keywords

  • Epidermis
  • Skin carcinogenesis
  • Stem cells

Fingerprint Dive into the research topics of 'A perspective on murine keratinocyte stem cells as targets of chemically induced skin cancer'. Together they form a unique fingerprint.

  • Cite this