A perspective on murine keratinocyte stem cells as targets of chemically induced skin cancer

Thaned Kangsamaksin; Joon Park Heui; Carol S. Trempus; Rebecca J. Morris

doi:10.1002/mc.20355

A perspective on murine keratinocyte stem cells as targets of chemically induced skin cancer

Thaned Kangsamaksin, Joon Park Heui, Carol S. Trempus, Rebecca J. Morris

Research output: Contribution to journal › Article › peer-review

41 Scopus citations

Abstract

Although ideas on the stem cell origins of cancer date more than one hundred years, critical evidence to support these theories is largely lacking. Our objective here is to outline our historical perspective on keratinocyte stem cells in the cutaneous epithelium and to summarize specific evidence suggesting that epithelial stem cells may contribute to chemically induced skin cancer. We note that, while strong evidence does support this hypothesis, experiments in progress may provide direct visualization of tumors derived from hair follicle stem cells.

Original language	English (US)
Pages (from-to)	579-584
Number of pages	6
Journal	Molecular Carcinogenesis
Volume	46
Issue number	8
DOIs	https://doi.org/10.1002/mc.20355
State	Published - Aug 2007
Externally published	Yes

Keywords

Epidermis
Skin carcinogenesis
Stem cells

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1002/mc.20355

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abstract = "Although ideas on the stem cell origins of cancer date more than one hundred years, critical evidence to support these theories is largely lacking. Our objective here is to outline our historical perspective on keratinocyte stem cells in the cutaneous epithelium and to summarize specific evidence suggesting that epithelial stem cells may contribute to chemically induced skin cancer. We note that, while strong evidence does support this hypothesis, experiments in progress may provide direct visualization of tumors derived from hair follicle stem cells.",

keywords = "Epidermis, Skin carcinogenesis, Stem cells",

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AU - Trempus, Carol S.

AU - Morris, Rebecca J.

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AB - Although ideas on the stem cell origins of cancer date more than one hundred years, critical evidence to support these theories is largely lacking. Our objective here is to outline our historical perspective on keratinocyte stem cells in the cutaneous epithelium and to summarize specific evidence suggesting that epithelial stem cells may contribute to chemically induced skin cancer. We note that, while strong evidence does support this hypothesis, experiments in progress may provide direct visualization of tumors derived from hair follicle stem cells.

KW - Epidermis

KW - Skin carcinogenesis

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A perspective on murine keratinocyte stem cells as targets of chemically induced skin cancer

Abstract

Keywords

UN SDGs

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