A patient-centered mobile health application to motivate use of genetic counseling among women with ovarian cancer: A pilot randomized controlled trial

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OBJECTIVE: Despite current guidelines recommending women with ovarian cancer receive genetic risk evaluation by a genetic counselor, utilization has historically been low. We sought to assess the feasibility and effectiveness of a week-long mobile Application for Genetic Information on Cancer (mAGIC) intervention aimed to persuade women with ovarian cancer to pursue genetic counseling.

METHODS: The mobile application intervention was based on the Fogg Behavior Model, and consisted of three parts: (1) identifying barriers, (2) developing motivators, and (3) providing triggers to action. The Health Belief Model was used to guide content development. We conducted a prospective, randomized, controlled pilot trial among 104 untested women with a history of epithelial ovarian, primary peritoneal or fallopian tube cancer with the primary objective of increasing uptake of cancer genetic counseling services.

RESULTS: Utilization of cancer genetic counseling services improved in both study arms over historical controls, however there was no statistically significant difference between them (intervention: 54.5% versus control: 38.6%; p = 0.14). However, compared to controls, women randomized to the mAGIC intervention demonstrated greater knowledge of hereditary cancer (0-10 scale; 9.4 ± 1.0 vs. 7.1 ± 1.5; p < 0.0001), which persisted for at least three months. Additionally, 96% of women in the intervention group reported they had talked with their family about genetic counseling compared to 77% in the control group (p = 0.01).

CONCLUSIONS: The mAGIC intervention did not result in increased uptake of genetic counseling, however it provided significant secondary benefits, including increased participants' knowledge about hereditary ovarian cancer, self-efficacy, and their reported communication with family members. ClinicalTrials.gov Identifier: NCT02877862.

Original languageEnglish (US)
Pages (from-to)100-107
Number of pages8
JournalGynecologic oncology
Issue number1
StatePublished - Apr 2019

Bibliographical note

Funding Information:
This work was funded by the Department of Defense Ovarian Cancer Research Program [ A-18144 ].

Publisher Copyright:
© 2019 Elsevier Inc.


  • BRCA
  • Communication
  • Genetic counseling
  • Mobile application
  • Ovarian cancer
  • Carcinoma, Ovarian Epithelial/genetics
  • Humans
  • Middle Aged
  • Health Knowledge, Attitudes, Practice
  • Telemedicine/methods
  • Genetic Counseling/methods
  • Pilot Projects
  • Mobile Applications
  • Female

PubMed: MeSH publication types

  • Research Support, U.S. Gov't, Non-P.H.S.
  • Randomized Controlled Trial
  • Journal Article


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