A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation

Jiaan Shao; Richard A. Houghten; Colette T. Dooley; Margret Cazares; Jay P. McLaughlin; Shainnel O. Eans; Michelle L. Ganno; Michelle R. Hoot; Marc A. Giulianotti; Yongping Yu

doi:10.1039/c7ob01924f

A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation

Jiaan Shao
, Richard A. Houghten
, Colette T. Dooley
, Margret Cazares
, Jay P. McLaughlin
, Shainnel O. Eans
, Michelle L. Ganno
, Michelle R. Hoot
, Marc A. Giulianotti
, Yongping Yu

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

A novel and facile domino reaction has been developed to synthesize a variety of new derivatives from hydromorphone, amines and paraformaldehyde in good yields in a catalyst-free fashion with high atom efficiency. The products show a mixed MOR/DOR biological characteristic which makes them valuable for further study as opioid analgesics.

Original language	English (US)
Pages (from-to)	7796-7801
Number of pages	6
Journal	Organic and Biomolecular Chemistry
Volume	15
Issue number	37
DOIs	https://doi.org/10.1039/c7ob01924f
State	Published - 2017
Externally published	Yes

Bibliographical note

Publisher Copyright:
© 2017 The Royal Society of Chemistry.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1039/c7ob01924f

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abstract = "A novel and facile domino reaction has been developed to synthesize a variety of new derivatives from hydromorphone, amines and paraformaldehyde in good yields in a catalyst-free fashion with high atom efficiency. The products show a mixed MOR/DOR biological characteristic which makes them valuable for further study as opioid analgesics.",

author = "Jiaan Shao and Houghten, \{Richard A.\} and Dooley, \{Colette T.\} and Margret Cazares and McLaughlin, \{Jay P.\} and Eans, \{Shainnel O.\} and Ganno, \{Michelle L.\} and Hoot, \{Michelle R.\} and Giulianotti, \{Marc A.\} and Yongping Yu",

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doi = "10.1039/c7ob01924f",

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TY - JOUR

T1 - A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation

AU - Shao, Jiaan

AU - Houghten, Richard A.

AU - Dooley, Colette T.

AU - Cazares, Margret

AU - McLaughlin, Jay P.

AU - Eans, Shainnel O.

AU - Ganno, Michelle L.

AU - Hoot, Michelle R.

AU - Giulianotti, Marc A.

AU - Yu, Yongping

PY - 2017

Y1 - 2017

N2 - A novel and facile domino reaction has been developed to synthesize a variety of new derivatives from hydromorphone, amines and paraformaldehyde in good yields in a catalyst-free fashion with high atom efficiency. The products show a mixed MOR/DOR biological characteristic which makes them valuable for further study as opioid analgesics.

AB - A novel and facile domino reaction has been developed to synthesize a variety of new derivatives from hydromorphone, amines and paraformaldehyde in good yields in a catalyst-free fashion with high atom efficiency. The products show a mixed MOR/DOR biological characteristic which makes them valuable for further study as opioid analgesics.

UR - https://www.scopus.com/pages/publications/85030261362

UR - https://www.scopus.com/pages/publications/85030261362#tab=citedBy

U2 - 10.1039/c7ob01924f

DO - 10.1039/c7ob01924f

M3 - Article

C2 - 28875208

AN - SCOPUS:85030261362

SN - 1477-0520

VL - 15

SP - 7796

EP - 7801

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 37

ER -

A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation

Abstract

Bibliographical note

UN SDGs

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