A once-a-month oral contraceptive

Ameya R. Kirtane; Tiffany Hua; Alison Hayward; Ambika Bajpayee; Aniket Wahane; Aaron Lopes; Taylor Bensel; Lihong Ma; Frank Z. Stanczyk; Sierra Brooks; Declan Gwynne; Jacob Wainer; Joy Collins; Siddartha M. Tamang; Robert Langer; Giovanni Traverso

doi:10.1126/scitranslmed.aay2602

A once-a-month oral contraceptive

Ameya R. Kirtane
, Tiffany Hua
, Alison Hayward
, Ambika Bajpayee
, Aniket Wahane
, Aaron Lopes
, Taylor Bensel
, Lihong Ma
, Frank Z. Stanczyk
, Sierra Brooks
, Declan Gwynne
, Jacob Wainer
, Joy Collins
, Siddartha M. Tamang
, Robert Langer
, Giovanni Traverso

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

Poor patient adherence to oral contraceptives is the predominant cause of failure of these therapies, leading to unplanned pregnancies that can negatively affect female health worldwide. To improve patient adherence, we developed an oral contraceptive that is administered once a month. Here, we describe the design and report in vivo characterization of a levonorgestrel-releasing gastric resident dosage form in pigs.

Original language	English (US)
Article number	eaay2602
Journal	Science Translational Medicine
Volume	11
Issue number	521
DOIs	https://doi.org/10.1126/scitranslmed.aay2602
State	Published - Dec 4 2019
Externally published	Yes

Bibliographical note

Publisher Copyright:
Copyright © 2019 The Authors.

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

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10.1126/scitranslmed.aay2602

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title = "A once-a-month oral contraceptive",

abstract = "Poor patient adherence to oral contraceptives is the predominant cause of failure of these therapies, leading to unplanned pregnancies that can negatively affect female health worldwide. To improve patient adherence, we developed an oral contraceptive that is administered once a month. Here, we describe the design and report in vivo characterization of a levonorgestrel-releasing gastric resident dosage form in pigs.",

author = "Kirtane, \{Ameya R.\} and Tiffany Hua and Alison Hayward and Ambika Bajpayee and Aniket Wahane and Aaron Lopes and Taylor Bensel and Lihong Ma and Stanczyk, \{Frank Z.\} and Sierra Brooks and Declan Gwynne and Jacob Wainer and Joy Collins and Tamang, \{Siddartha M.\} and Robert Langer and Giovanni Traverso",

note = "Publisher Copyright: Copyright {\textcopyright} 2019 The Authors.",

year = "2019",

month = dec,

day = "4",

doi = "10.1126/scitranslmed.aay2602",

language = "English (US)",

volume = "11",

journal = "Science Translational Medicine",

issn = "1946-6234",

publisher = "American Association for the Advancement of Science",

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T1 - A once-a-month oral contraceptive

AU - Kirtane, Ameya R.

AU - Hua, Tiffany

AU - Hayward, Alison

AU - Bajpayee, Ambika

AU - Wahane, Aniket

AU - Lopes, Aaron

AU - Bensel, Taylor

AU - Ma, Lihong

AU - Stanczyk, Frank Z.

AU - Brooks, Sierra

AU - Gwynne, Declan

AU - Wainer, Jacob

AU - Collins, Joy

AU - Tamang, Siddartha M.

AU - Langer, Robert

AU - Traverso, Giovanni

PY - 2019/12/4

Y1 - 2019/12/4

N2 - Poor patient adherence to oral contraceptives is the predominant cause of failure of these therapies, leading to unplanned pregnancies that can negatively affect female health worldwide. To improve patient adherence, we developed an oral contraceptive that is administered once a month. Here, we describe the design and report in vivo characterization of a levonorgestrel-releasing gastric resident dosage form in pigs.

AB - Poor patient adherence to oral contraceptives is the predominant cause of failure of these therapies, leading to unplanned pregnancies that can negatively affect female health worldwide. To improve patient adherence, we developed an oral contraceptive that is administered once a month. Here, we describe the design and report in vivo characterization of a levonorgestrel-releasing gastric resident dosage form in pigs.

UR - https://www.scopus.com/pages/publications/85076287734

UR - https://www.scopus.com/pages/publications/85076287734#tab=citedBy

U2 - 10.1126/scitranslmed.aay2602

DO - 10.1126/scitranslmed.aay2602

M3 - Article

C2 - 31801885

AN - SCOPUS:85076287734

SN - 1946-6234

VL - 11

JO - Science Translational Medicine

JF - Science Translational Medicine

IS - 521

M1 - eaay2602

ER -

A once-a-month oral contraceptive

Abstract

Bibliographical note

UN SDGs

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