A novel therapeutic approach to depression via supplement with tyrosine hydroxylase

Ai Ling Fu, Shaoping Wu, Zhao Hui Dong, Man Ji Sun

Research output: Contribution to journalArticlepeer-review

27 Scopus citations

Abstract

Tyrosine hydroxylase (tyrosine 3-monooxygenase, EC 1.14.16.2, TH) is the rate-limiting enzyme in the biosynthesis of catecholamine neurotransmitters, dopamine (DA), noradrenaline (NE), and adrenaline, in the neurons. The regulated activity of TH is thought to play a critical role in modulating the functional activity of catecholaminergic neuronal systems in the brain. It is well known that the catecholaminergic neuronal systems are associated with depression. Here we showed that TH, delivered by protein transduction domain (PTD), passed through the blood-brain barrier and entered the neurons. Systemic TH treatment improved the behavioral despair in the forced swim test (FST) and the tail suspension test (TST), the two models widely used to screen the potential anti-depressant efficacy. The results indicated a novel and potential therapeutic use of TH in the depression disorder.

Original languageEnglish (US)
Pages (from-to)140-145
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume351
Issue number1
DOIs
StatePublished - Dec 8 2006

Keywords

  • Anti-depressant
  • Depression
  • Protein therapy
  • Protein transduction domain
  • Tyrosine hydroxylase

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