A novel terpenoid class for prevention and treatment of KRAS-driven cancers: Comprehensive analysis using in situ, in vitro, and in vivo model systems

Keyphrases

• In Vivo Model Systems 100%
• In Situ 100%
• Terpenoids 100%
• KRAS Protein 100%
• Disease Progression 66%
• Lupeol 66%
• Activated Cells 66%
• Pancreatic Intraepithelial Neoplasia (PanIN) 66%
• KRAS Signaling 66%
• Lung 33%
• Transgenic Mouse Model 33%
• Triterpenes 33%
• Molecular Pathways 33%
• Protein Activity 33%
• Preventive Treatment 33%
• In Silico 33%
• Pancreatic Ductal Adenocarcinoma 33%
• Patient Tumor 33%
• Pharmacokinetic Analysis 33%
• New Agents 33%
• Isothermal Titration Calorimetry 33%
• Progression Model 33%
• Oral Route 33%
• Guanosine Triphosphate 33%
• Immunoprecipitation Assay 33%
• Tumor Explant 33%
• Nucleotide Exchange 33%
• Three-dimensional Growth 33%
• Treatment Agent 33%
• Intraperitoneal Route 33%
• Biological Validation 33%
• Differential Scanning Fluorimetry 33%
• Chemical Families 33%
• In Silico Data 33%
• KRAS Inhibitors 33%
• Effective Intervention 33%
• Protein Binding Affinity 33%
• Cre Mice 33%
• Guanosine Diphosphate 33%
• Patient-derived Explants 33%
• KRAS G12C 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Terpenoid 100%
• Disease Exacerbation 66%
• Lupeol 66%
• Pancreas Adenoma 66%
• Protein Binding 33%
• Transgenic Mouse 33%
• Mouse Model 33%
• Differential Scanning Calorimetry 33%
• Immunoprecipitation 33%
• Pancreas Adenocarcinoma 33%
• Bioavailability 33%
• Neoplasm 33%
• Guanosine Triphosphate 33%
• Triterpene 33%
• Guanosine Diphosphate 33%
• Pharmacokinetics 33%

Biochemistry, Genetics and Molecular Biology

• KRAS 100%
• Explant 14%
• Mouse Model 7%
• Binding Protein 7%
• Crystal Structure 7%
• Differential Scanning Calorimetry 7%
• Immunoprecipitation 7%
• Transgenic Mouse 7%
• Binding Affinity 7%
• Isothermal Titration Calorimetry 7%
• Pharmacokinetics 7%
• Guanosine Triphosphate 7%
• Guanosine Diphosphate 7%