A novel role for SALL4 during scar-free wound healing in axolotl

Jami R. Erickson, Micah D. Gearhart, Drew D. Honson, Taylor A. Reid, Melissa K Gardner, Branden S. Moriarity, Karen Echeverri

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The human response to serious cutaneous damage is limited to relatively primitive wound healing, whereby collagenous scar tissue fills the wound bed. Scars assure structural integrity at the expense of functional regeneration. In contrast, axolotls have the remarkable capacity to functionally regenerate full thickness wounds. Here, we identified a novel role for SALL4 in regulating collagen transcription after injury that is essential for perfect skin regeneration in axolotl. Furthermore, we identify miR-219 as a molecular regulator of Sall4 during wound healing. Taken together, our work highlights one molecular mechanism that allows for efficient cutaneous wound healing in the axolotl.

Original languageEnglish (US)
Article number16016
JournalRegenerative Medicine
Volume1
Issue number1
DOIs
StatePublished - Dec 8 2016

Bibliographical note

Publisher Copyright:
© The Author(s) 2016.

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  • Open Access Publishing Fund

    Sims, N. A. (Key Personnel)

    3/1/12 → …

    Project: Other project

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