A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries

Marc A. Giulianotti; Ginamarie Debevec; Radleigh G. Santos; Laura E. Maida; Wenteng Chen; Lili Ou; Yongping Yu; Colette T. Dooley; Richard A. Houghten

doi:10.1021/co300060s

A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries

Marc A. Giulianotti
, Ginamarie Debevec
, Radleigh G. Santos
, Laura E. Maida
, Wenteng Chen
, Lili Ou
, Yongping Yu
, Colette T. Dooley
, Richard A. Houghten

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

A novel method for the direct evaluation of the equimolarity of the compounds contained in a mixture is presented. We applied the method toward calculating isokinetic ratios for the reaction between the amine termini of a resin bound peptide fragment and a sulfonyl chloride to produce equal molar mixtures of sulfonamides. The results of this study and the application of the method to the synthesis of two new positional scanning synthetic combinatorial libraries (PS-SCL) are discussed.

Original language	English (US)
Pages (from-to)	503-512
Number of pages	10
Journal	ACS Combinatorial Science
Volume	14
Issue number	9
DOIs	https://doi.org/10.1021/co300060s
State	Published - Sep 10 2012
Externally published	Yes

Keywords

combinatorial libraries
guanidine
harmonic mean
isokinetic ratios
piperazine
positional scanning library
sulfonamide

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10.1021/co300060s

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title = "A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries",

abstract = "A novel method for the direct evaluation of the equimolarity of the compounds contained in a mixture is presented. We applied the method toward calculating isokinetic ratios for the reaction between the amine termini of a resin bound peptide fragment and a sulfonyl chloride to produce equal molar mixtures of sulfonamides. The results of this study and the application of the method to the synthesis of two new positional scanning synthetic combinatorial libraries (PS-SCL) are discussed.",

keywords = "combinatorial libraries, guanidine, harmonic mean, isokinetic ratios, piperazine, positional scanning library, sulfonamide",

author = "Giulianotti, \{Marc A.\} and Ginamarie Debevec and Santos, \{Radleigh G.\} and Maida, \{Laura E.\} and Wenteng Chen and Lili Ou and Yongping Yu and Dooley, \{Colette T.\} and Houghten, \{Richard A.\}",

year = "2012",

month = sep,

day = "10",

doi = "10.1021/co300060s",

language = "English (US)",

volume = "14",

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TY - JOUR

T1 - A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries

AU - Giulianotti, Marc A.

AU - Debevec, Ginamarie

AU - Santos, Radleigh G.

AU - Maida, Laura E.

AU - Chen, Wenteng

AU - Ou, Lili

AU - Yu, Yongping

AU - Dooley, Colette T.

AU - Houghten, Richard A.

PY - 2012/9/10

Y1 - 2012/9/10

N2 - A novel method for the direct evaluation of the equimolarity of the compounds contained in a mixture is presented. We applied the method toward calculating isokinetic ratios for the reaction between the amine termini of a resin bound peptide fragment and a sulfonyl chloride to produce equal molar mixtures of sulfonamides. The results of this study and the application of the method to the synthesis of two new positional scanning synthetic combinatorial libraries (PS-SCL) are discussed.

AB - A novel method for the direct evaluation of the equimolarity of the compounds contained in a mixture is presented. We applied the method toward calculating isokinetic ratios for the reaction between the amine termini of a resin bound peptide fragment and a sulfonyl chloride to produce equal molar mixtures of sulfonamides. The results of this study and the application of the method to the synthesis of two new positional scanning synthetic combinatorial libraries (PS-SCL) are discussed.

KW - combinatorial libraries

KW - guanidine

KW - harmonic mean

KW - isokinetic ratios

KW - piperazine

KW - positional scanning library

KW - sulfonamide

UR - https://www.scopus.com/pages/publications/84866095427

UR - https://www.scopus.com/pages/publications/84866095427#tab=citedBy

U2 - 10.1021/co300060s

DO - 10.1021/co300060s

M3 - Article

C2 - 22913403

AN - SCOPUS:84866095427

SN - 2156-8952

VL - 14

SP - 503

EP - 512

JO - ACS Combinatorial Science

JF - ACS Combinatorial Science

IS - 9

ER -

A novel method for the determination of isokinetic ratios and its application in the synthesis of two new positional scanning libraries

Abstract

Keywords

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