A novel lead design for modulation and sensing of deep brain structures

Allison T. Connolly, Rio J. Vetter, Jamille F. Hetke, Benjamin A. Teplitzky, Daryl R. Kipke, David S. Pellinen, David J. Anderson, Kenneth B. Baker, Jerrold L. Vitek, Matthew D. Johnson

Research output: Contribution to journalArticlepeer-review

34 Scopus citations

Abstract

Goal: Develop and characterize the functionality of a novel thin-film probe technology with a higher density of electrode contacts than are currently available with commercial deep brain stimulation (DBS) lead technology. Such technology has potential to enhance the spatial precision of DBS and enable a more robust approach to sensing local field potential activity in the context of adaptive DBS strategies. Methods: Thin-film planar arrays were microfabricated and then assembled on a cylindrical carrier to achieve a lead with 3-D conformation. Using an integrated and removable stylet, the arrays were chronically implanted in the subthalamic nucleus and globus pallidus in two parkinsonian nonhuman primates. Results: This study provides the first in vivo data from chronically implanted DBS arrays for translational nonhuman primate studies. Stimulation through the arrays induced a decrease in parkinsonian rigidity, and directing current around the lead showed an orientation dependence for eliciting motor capsule side effects. The array recordings also showed that oscillatory activity in the basal ganglia is heterogeneous at a smaller scale than detected by the current DBS lead technology. Conclusion: These 3-D DBS arrays provide an enabling tool for future studies that seek to monitor and modulate deep brain activity through chronically implanted leads. Significance: DBS lead technology with a higher density of electrode contacts has potential to enable sculpting DBS current flow and sensing biomarkers of disease and therapy.

Original languageEnglish (US)
Article number7310867
Pages (from-to)148-157
Number of pages10
JournalIEEE Transactions on Biomedical Engineering
Volume63
Issue number1
DOIs
StatePublished - Jan 2016

Bibliographical note

Publisher Copyright:
© 2015 IEEE.

Keywords

  • Current steering
  • Deep brain stimulation (DBS)
  • Implantable biomedical electrodes
  • Neural engineering

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