A novel imaging-compatible sciatic nerve schwannoma model

Okay Saydam, Gokhan Baris Ozdener, Ozlem Senol, Arda Mizrak, Shilpa Prabhakar, Anat O. Stemmer-Rachamimov, Xandra O. Breakefield, Gary J. Brenner

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Benign schwannomas are common tumors of the cranial and peripheral nerves, causing pain and loss of function. The development of effective therapy for these tumors has been hampered by the lack of relevant experimental in vivo models for convenient testing. Here, we describe a novel schwannoma model in which an immortalized human schwannoma cell line, HEI-193, established from an neurofibromatosis type 2 patient, has been stably transduced with fluorescent protein and luciferase reporters and implanted within the sciatic nerve of nude mice. These cells reliably formed a tumor within several weeks which had pathologic characteristics of schwannoma tumors. This model system will be useful for investigation of schwannoma biology and for preclinical assessment of therapeutic agents.

Original languageEnglish (US)
Pages (from-to)75-77
Number of pages3
JournalJournal of Neuroscience Methods
Volume195
Issue number1
DOIs
StatePublished - Jan 30 2011
Externally publishedYes

Keywords

  • NF2
  • Schwannoma
  • Sciatic nerve tumor model

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