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A novel CYP2A6 allele (CYP2A6* 35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo
Nael Al Koudsi
, Jasjit S. Ahluwalia
, Shih Ku Lin
, Edward M. Sellers
, Rachel F. Tyndale
Medicine - General Internal Medicine
Research output
:
Contribution to journal
›
Article
›
peer-review
44
Scopus citations
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Dive into the research topics of 'A novel CYP2A6 allele (CYP2A6* 35) resulting in an amino-acid substitution (Asn438Tyr) is associated with lower CYP2A6 activity in vivo'. Together they form a unique fingerprint.
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Keyphrases
Amino Acid Substitution
100%
Activity in Vivo
100%
Cytochrome P450 2D6 (CYP2D6)
100%
Nicotine
13%
Allele Frequency
13%
Nicotine Metabolism
6%
African Ancestry
6%
Frequency Effect
6%
Thermal Stability
6%
Black African
6%
NsSNPs
6%
Activity Stability
6%
Novel Allele
6%
(C) Oxidation
6%
Oxidation Behavior
6%
Human Enzymes
6%
Immunology and Microbiology
Amino Acid Substitution
100%
Allele
100%
Cytochrome P450
100%
Gene Frequency
13%
In Vitro
13%
Single Nucleotide Polymorphism
6%
Thermostability
6%
Haplotype
6%
Agricultural and Biological Sciences
Allele
100%
Amino Acid Substitution
100%
CYP2A6
100%
Gene Frequency
13%
Haplotype
6%
Single Nucleotide Polymorphism
6%