A Novel Benzocoumarin-Stilbene Hybrid as a DNA ligase i inhibitor with in vitro and in vivo anti-tumor activity in breast cancer models

Keyphrases

• Breast Cancer Model 100%
• Antiproliferative Activity 100%
• In Vivo Antitumor Activity 100%
• DNA Ligase 100%
• Stilbenes 100%
• Benzocoumarin 100%
• Cell Biology 50%
• Novel Therapeutics 50%
• Breast Cancer 50%
• Tumor Growth 50%
• Cancer Cell Lines 50%
• Poor Prognosis 50%
• Cancer Therapy 50%
• Drug Resistance 50%
• Tumor Size 50%
• Human DNA 50%
• Cellular Targets 50%
• Enzyme Activity 50%
• Drug Toxicity 50%
• Mouse Tumor Model 50%
• Novel Class 50%
• Biophysical Approach 50%
• Benzo 50%
• 4T1 Cells 50%
• Syngeneic Mice 50%
• MDA-MB-231 Cancer Cells 50%
• Mouse Breast Cancer 50%
• Hybrid Molecules 50%
• 2H-chromen-2-one 50%
• Mechanistic Studies 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Malignant Neoplasm 100%
• Breast Cancer 100%
• Cancer Model 100%
• Stilbene 100%
• Neoplasm 100%
• DNA Ligase 100%
• Antiproliferative Activity 50%
• Mouse Model 25%
• Antitumor Activity 25%
• Tumor Growth 25%
• Recurrent Disease 25%
• Drug Toxicity 25%
• Drug Resistance 25%