A novel array of interface-confined molecules: Assembling natural segments for delivery of multi-functionalities

Sampson Anankanbil, Bianca Pérez, Jingwen Yang, Chiranjib Banerjee, Zheng Guo

Research output: Contribution to journalArticlepeer-review

11 Scopus citations


Hypothesis Anionic surfactants can form stable monolayers around oil droplets via interactions with macromolecules thereby physically stabilizing high fish oil enriched emulsions (50–70% fish oil) while phenolic acids have antioxidant properties to prevent lipid oxidation. COSMO-RS (Conductor-like Screening Model for Real Solvents) is a powerful tool for the rational design of molecules with multi-functionalities. Therefore, it should be possible to assemble segments of natural molecules into a single multifunctional molecule using COSMO-RS to confer both physical and oxidative stability to fish oil enriched systems. Experiments COSMO-RS was used to predict the thermodynamic properties of series phenoleoyl malic acid esters of monoglycerides in comparison with commercial emulsifiers. A novel series of amphiphilic lipids, equipped with multi-functional groups from natural building blocks (fatty-acyl, glycerol, malic & phenolic acids), were then synthesized in a facile approach and characterized by various spectroscopy techniques. Oil-in-water emulsions stabilized by the amphiphilic lipids were formulated and characterized by dynamic light scattering measurements and fluorescence imaging. Findings An elaborate integration of multi-functions into a single molecule was achieved, displaying superior or comparable emulsion stability and antioxidant property, compared to a commercial emulsifier, phenolic acids and their combinations. This is the first report to holistically integrate the rational design, synthesis and functional characterization of natural-based multifunctional molecules for high capacity fish oil delivery systems.

Original languageEnglish (US)
Pages (from-to)230-236
Number of pages7
JournalJournal of Colloid And Interface Science
StatePublished - Dec 15 2017

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Inc.


  • Antioxidant
  • Dual functionality
  • Fish oil-in-water emulsions
  • Interfacial activity
  • Lipid oxidation
  • Rational design


Dive into the research topics of 'A novel array of interface-confined molecules: Assembling natural segments for delivery of multi-functionalities'. Together they form a unique fingerprint.

Cite this