A novel and efficient route for synthesis of Taladegib

Keyphrases

• Debenzylation 100%
• Efficient Route 100%
• Biological Evaluation 50%
• Small Molecules 50%
• Large-scale Production 50%
• Trifluoromethyl 50%
• Reductive Amination 50%
• Fluoro 50%
• 1H-pyrazole 50%
• Hedgehog Inhibitor 50%
• Acylation 50%
• Synthetic Procedures 50%
• Benzoyl Chloride 50%
• Hydrogen Source 50%
• Boronic Acid 50%
• Reaction Yield 50%
• Ammonium Formate 50%
• Fmoc Deprotection 50%
• Operational Procedures 50%
• Boc Protection 50%
• Synthesis Routes 50%
• 1-methyl 50%
• Suzuki Cross-coupling Reaction 50%
• N-benzyl-4-piperidone 50%

Chemistry

• Debenzylation 100%
• Reaction Yield 50%
• Boronic Acid 50%
• Piperidones 50%
• 1H-Pyrazole 50%
• Ammonium Formate 50%
• Borch Reduction 50%
• Pathway Inhibitor 50%
• Benzoyl Chloride 50%
• Signal Transduction 50%
• Acylation 50%
• Suzuki Reaction 50%
• Hydrogen 50%