A novel alternative placement site and technique for totally implantable vascular access ports in non-human primates

Melanie L. Graham, Eric F. Rieke, Michele Dunning, Lucas A. Mutch, Angela M. Craig, Elizabeth K. Zolondek, Bernhard J. Hering, Henk Jan Schuurman, Richard W. Bianco

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

Background: Two novel approaches to implanting a central venous catheter port in non-human primates (NHPs) using peripheral insertion are presented and compared. Methods: Sixty vascular access port (VAP) implants were attempted in 52 NHPs by saphenous vein puncture (n = 20) or saphenous vein cutdown (n = 40). Results: Fifty eight procedures were successful. Eighteen of 20 VAPs were successfully placed using saphenous vein puncture, and 40 of 40 using saphenous vein cutdown. There were no significant differences between procedures. Mean implantation times were similar between groups. At explant or study endpoint, all 58 VAPs were patent. Conclusions: Vascular access port implantation by saphenous vein puncture or saphenous vein cutdown is safe and effective in NHPs. It is less invasive than conventional procedures, has fewer complications, provides outstanding patency, and reduces surgery time. Furthermore, it allows for cooperative in-homecage VAP use, minimizing handling stress. We recommend these refined methods for long-term vascular access in NHPs.

Original languageEnglish (US)
Pages (from-to)204-212
Number of pages9
JournalJournal of Medical Primatology
Volume38
Issue number3
DOIs
StatePublished - Jun 5 2009

Keywords

  • Blood collection
  • Central venous catheterization
  • Indwelling catheter
  • Macaca
  • Refinement

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