A non-invasive, quantitative study of broadband spectral responses in human visual cortex

Eline R. Kupers, Helena X. Wang, Kaoru Amano, Kendrick N Kay, David J. Heeger, Jonathan Winawer

Research output: Contribution to journalArticle

Abstract

Currently, non-invasive methods for studying the human brain do not routinely and reliably measure spike-rate-dependent signals, independent of responses such as hemodynamic coupling (fMRI) and subthreshold neuronal synchrony (oscillations and event-related potentials). In contrast, invasive methods—microelectrode recordings and electrocorticography (ECoG)—have recently measured broadband power elevation in field potentials (~50–200 Hz) as a proxy for locally averaged spike rates. Here, we sought to detect and quantify stimulus-related broadband responses using magnetoencephalography (MEG). Extracranial measurements like MEG and EEG have multiple global noise sources and relatively low signal-to-noise ratios; moreover high frequency artifacts from eye movements can be confounded with stimulus design and mistaken for signals originating from brain activity. For these reasons, we developed an automated denoising technique that helps reveal the broadband signal of interest. Subjects viewed 12-Hz contrast-reversing patterns in the left, right, or bilateral visual field. Sensor time series were separated into evoked (12-Hz amplitude) and broadband components (60–150 Hz). In all subjects, denoised broadband responses were reliably measured in sensors over occipital cortex, even in trials without microsaccades. The broadband pattern was stimulus-dependent, with greater power contralateral to the stimulus. Because we obtain reliable broadband estimates with short experiments (~20 minutes), and with sufficient signal-to-noise to distinguish responses to different stimuli, we conclude that MEG broadband signals, denoised with our method, offer a practical, non-invasive means for characterizing spike-rate-dependent neural activity for addressing scientific questions about human brain function.

Original languageEnglish (US)
Article numbere0193107
JournalPloS one
Volume13
Issue number3
DOIs
StatePublished - Mar 1 2018

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Magnetoencephalography
Visual Cortex
Brain
brain
sensors (equipment)
Noise
Occipital Lobe
Eye movements
Sensors
Hemodynamics
Signal-To-Noise Ratio
Proxy
hemodynamics
Eye Movements
Electroencephalography
Visual Fields
Evoked Potentials
Artifacts
oscillation
Time series

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural

Cite this

A non-invasive, quantitative study of broadband spectral responses in human visual cortex. / Kupers, Eline R.; Wang, Helena X.; Amano, Kaoru; Kay, Kendrick N; Heeger, David J.; Winawer, Jonathan.

In: PloS one, Vol. 13, No. 3, e0193107, 01.03.2018.

Research output: Contribution to journalArticle

Kupers, Eline R. ; Wang, Helena X. ; Amano, Kaoru ; Kay, Kendrick N ; Heeger, David J. ; Winawer, Jonathan. / A non-invasive, quantitative study of broadband spectral responses in human visual cortex. In: PloS one. 2018 ; Vol. 13, No. 3.
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