A new software method for accurate mass measurements of drugs on unit mass resolution mass spectrometer

Ke Liu; Bin Ma; Yong Dong Wang; Xiao Yan Chen; Da Fang Zhong

A new software method for accurate mass measurements of drugs on unit mass resolution mass spectrometer

Ke Liu
, Bin Ma
, Yong Dong Wang
, Xiao Yan Chen
, Da Fang Zhong

Carcinogenesis and Chemoprevention

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Accurate mass measurements of 20 drugs were conducted using MassWorks software on a TSQ Quantum Ultra mass spectrometer. All Q1 scan mass spectral data were collected in profile mode with full width at half-maximum (FWHM) set at 0. 7 Da. The mass errors of all 20 drugs (molecular weight between 135 and 810) were within the range from - 22. 4 × 10^-6 to 36. 1 × 10^-6, among them 90% of the drugs achieved a mass accuracy better than 10 × 10^-6. The new method can provide accurate mass measurements on unit mass resolution mass spectrometers.

Original language	English (US)
Pages (from-to)	1112-1114
Number of pages	3
Journal	Yaoxue Xuebao
Volume	42
Issue number	10
State	Published - Oct 1 2007

Keywords

Accurate relative molecular mass
Isotope
Unit mass resolution mass spectrometer

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title = "A new software method for accurate mass measurements of drugs on unit mass resolution mass spectrometer",

abstract = "Accurate mass measurements of 20 drugs were conducted using MassWorks software on a TSQ Quantum Ultra mass spectrometer. All Q1 scan mass spectral data were collected in profile mode with full width at half-maximum (FWHM) set at 0. 7 Da. The mass errors of all 20 drugs (molecular weight between 135 and 810) were within the range from - 22. 4 × 10-6 to 36. 1 × 10-6, among them 90\% of the drugs achieved a mass accuracy better than 10 × 10-6. The new method can provide accurate mass measurements on unit mass resolution mass spectrometers.",

keywords = "Accurate relative molecular mass, Isotope, Unit mass resolution mass spectrometer",

author = "Ke Liu and Bin Ma and Wang, \{Yong Dong\} and Chen, \{Xiao Yan\} and Zhong, \{Da Fang\}",

year = "2007",

month = oct,

day = "1",

language = "English (US)",

volume = "42",

pages = "1112--1114",

journal = "Yaoxue Xuebao",

issn = "0513-4870",

publisher = "Chinese Pharmaceutical Association",

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TY - JOUR

T1 - A new software method for accurate mass measurements of drugs on unit mass resolution mass spectrometer

AU - Liu, Ke

AU - Ma, Bin

AU - Wang, Yong Dong

AU - Chen, Xiao Yan

AU - Zhong, Da Fang

PY - 2007/10/1

Y1 - 2007/10/1

N2 - Accurate mass measurements of 20 drugs were conducted using MassWorks software on a TSQ Quantum Ultra mass spectrometer. All Q1 scan mass spectral data were collected in profile mode with full width at half-maximum (FWHM) set at 0. 7 Da. The mass errors of all 20 drugs (molecular weight between 135 and 810) were within the range from - 22. 4 × 10-6 to 36. 1 × 10-6, among them 90% of the drugs achieved a mass accuracy better than 10 × 10-6. The new method can provide accurate mass measurements on unit mass resolution mass spectrometers.

AB - Accurate mass measurements of 20 drugs were conducted using MassWorks software on a TSQ Quantum Ultra mass spectrometer. All Q1 scan mass spectral data were collected in profile mode with full width at half-maximum (FWHM) set at 0. 7 Da. The mass errors of all 20 drugs (molecular weight between 135 and 810) were within the range from - 22. 4 × 10-6 to 36. 1 × 10-6, among them 90% of the drugs achieved a mass accuracy better than 10 × 10-6. The new method can provide accurate mass measurements on unit mass resolution mass spectrometers.

KW - Accurate relative molecular mass

KW - Isotope

KW - Unit mass resolution mass spectrometer

UR - https://www.scopus.com/pages/publications/42149132156

UR - https://www.scopus.com/pages/publications/42149132156#tab=citedBy

M3 - Article

C2 - 18229624

AN - SCOPUS:42149132156

SN - 0513-4870

VL - 42

SP - 1112

EP - 1114

JO - Yaoxue Xuebao

JF - Yaoxue Xuebao

IS - 10

ER -

A new software method for accurate mass measurements of drugs on unit mass resolution mass spectrometer

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