A new software method for accurate mass measurements of drugs on unit mass resolution mass spectrometer

Ke Liu, Bin Ma, Yong Dong Wang, Xiao Yan Chen, Da Fang Zhong

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Accurate mass measurements of 20 drugs were conducted using MassWorks software on a TSQ Quantum Ultra mass spectrometer. All Q1 scan mass spectral data were collected in profile mode with full width at half-maximum (FWHM) set at 0. 7 Da. The mass errors of all 20 drugs (molecular weight between 135 and 810) were within the range from - 22. 4 × 10-6 to 36. 1 × 10-6, among them 90% of the drugs achieved a mass accuracy better than 10 × 10-6. The new method can provide accurate mass measurements on unit mass resolution mass spectrometers.

Original languageEnglish (US)
Pages (from-to)1112-1114
Number of pages3
JournalYaoxue Xuebao
Volume42
Issue number10
StatePublished - Oct 1 2007

Keywords

  • Accurate relative molecular mass
  • Isotope
  • Unit mass resolution mass spectrometer

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