A new role for phospholipase A2: protection of membranes from lipid peroxidation damage

Frederik J.G.M. van Kuijk, Alex Sevanian, Garry J. Handelman, Edward A. Dratz

Research output: Contribution to journalArticlepeer-review

360 Scopus citations


Recently it was discovered that phospholipase A2 preferentially hydrolyses peroxidized fatty acid esters in phospholipid membranes. Release of the peroxidized fatty acids from the membrane was found to be an absolute requirement for glutathione peroxidase to reduce and detoxify fatty acid hydroperoxides in membranes. On the basis of these findings we propose a new role for phospholipase A2 in protecting membranes from oxidative injury.

Original languageEnglish (US)
Pages (from-to)31-34
Number of pages4
JournalTrends in Biochemical Sciences
Issue numberC
StatePublished - 1987

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