A new role for phospholipase A2: protection of membranes from lipid peroxidation damage

Frederik J.G.M. van Kuijk; Alex Sevanian; Garry J. Handelman; Edward A. Dratz

doi:10.1016/0968-0004(87)90014-4

A new role for phospholipase A₂: protection of membranes from lipid peroxidation damage

Frederik J.G.M. van Kuijk, Alex Sevanian, Garry J. Handelman, Edward A. Dratz

Ophthalmology & Visual Neurosciences

Research output: Contribution to journal › Article › peer-review

360 Scopus citations

Abstract

Recently it was discovered that phospholipase A₂ preferentially hydrolyses peroxidized fatty acid esters in phospholipid membranes. Release of the peroxidized fatty acids from the membrane was found to be an absolute requirement for glutathione peroxidase to reduce and detoxify fatty acid hydroperoxides in membranes. On the basis of these findings we propose a new role for phospholipase A₂ in protecting membranes from oxidative injury.

Original language	English (US)
Pages (from-to)	31-34
Number of pages	4
Journal	Trends in Biochemical Sciences
Volume	12
Issue number	C
DOIs	https://doi.org/10.1016/0968-0004(87)90014-4
State	Published - 1987

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title = "A new role for phospholipase A2: protection of membranes from lipid peroxidation damage",

abstract = "Recently it was discovered that phospholipase A2 preferentially hydrolyses peroxidized fatty acid esters in phospholipid membranes. Release of the peroxidized fatty acids from the membrane was found to be an absolute requirement for glutathione peroxidase to reduce and detoxify fatty acid hydroperoxides in membranes. On the basis of these findings we propose a new role for phospholipase A2 in protecting membranes from oxidative injury.",

author = "{van Kuijk}, {Frederik J.G.M.} and Alex Sevanian and Handelman, {Garry J.} and Dratz, {Edward A.}",

year = "1987",

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AU - Dratz, Edward A.

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AB - Recently it was discovered that phospholipase A2 preferentially hydrolyses peroxidized fatty acid esters in phospholipid membranes. Release of the peroxidized fatty acids from the membrane was found to be an absolute requirement for glutathione peroxidase to reduce and detoxify fatty acid hydroperoxides in membranes. On the basis of these findings we propose a new role for phospholipase A2 in protecting membranes from oxidative injury.

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