A new role for phospholipase A2: protection of membranes from lipid peroxidation damage

Frederik J.G.M. van Kuijk, Alex Sevanian, Garry J. Handelman, Edward A. Dratz

Research output: Contribution to journalArticlepeer-review

386 Scopus citations


Recently it was discovered that phospholipase A2 preferentially hydrolyses peroxidized fatty acid esters in phospholipid membranes. Release of the peroxidized fatty acids from the membrane was found to be an absolute requirement for glutathione peroxidase to reduce and detoxify fatty acid hydroperoxides in membranes. On the basis of these findings we propose a new role for phospholipase A2 in protecting membranes from oxidative injury.

Original languageEnglish (US)
Pages (from-to)31-34
Number of pages4
JournalTrends in Biochemical Sciences
Issue numberC
StatePublished - 1987

Bibliographical note

Funding Information:
~domacc id( 20 4) catet hatt hel evelo f phosphohpaAse 2 Concludinrge marks actlwtyis alsoi ncreaseidn proporttotno The datas ummarizeadb ovein dicate thed egreeo f hpldp eroxldatlomn phos-thatp hosFhohpasAe2 has an essential phohpldm embran1e9s funcUonm the detoxaficaUoonf phos-phohp~pde roxidesIf hp\]dp eroxideasr e notr emovetdh eyc anb reakd ownt ofree Acknowkdgements radical productsw hich mluatec hain Thts work was supportedb y grants reactiontso p roducme oreh ptdp eroxides from the NetherlandOsr ganizatiofno r Dp~dp eroyadecsa na lsob reakd ownt o the Advancemenotf Pure Research otherr eacavper oductssu cha sa ldehydes (ZWO) (to FJGMvK) and the US metabohs2m4 PhosphohpasAe2 prefe-wheh can greatly d~sturbc ellular NatmnaIln stituteosf Health( to EAD


Dive into the research topics of 'A new role for phospholipase A2: protection of membranes from lipid peroxidation damage'. Together they form a unique fingerprint.

Cite this