A new MMPI-derived indicator of liability to develop schizophrenia: Evidence from the New York High-Risk Project

P. Kevin Bolinskey, Irving I. Gottesman, David S. Nichols, Barbara M. Shapiro, Simone A. Roberts, Ulla H. Adamo, L. Erlenmeyer-Kimling

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

A large body of research indicates that the liability to develop schizophrenia is largely genetically mediated, although phenotypic expression requires environmental triggers/insults and/or epigenetic and/or stochastic factors. In an effort to identify the precise environmental factors that precipitate a predisposition to schizophrenia, researchers have implemented a high-risk model - the prospective study of offspring born to schizophrenic parents. As it is difficult to ascertain exactly which of the "high-risk" participants will actually develop the disorder, we examined the validity of an experimental MMPI scale, Schizophrenia Proneness (SzP), and the Moldin-Gottesman psychometric index to identify such individuals. Results suggest that the SzP scale can be an effective predictor of schizophrenia-related psychoses. A revised psychometric index is offered for further study.

Original languageEnglish (US)
Pages (from-to)127-143
Number of pages17
JournalAssessment
Volume8
Issue number2
DOIs
StatePublished - Jun 2001

Keywords

  • Genetics
  • MMPI
  • New York High-Risk Project
  • Offspring of schizophrenics
  • Schizophrenia

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