A new look at the stress index for lung injury

P. S. Crooke, J. J. Marini, J. R. Hotchkiss

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Ranieri and colleagues 1,2 have proposed a simple mathematical equation (Paw(t) ≈ atb + c) where a, b, and c are constants that relates airway pressure, Paw(t), over inspiration (0 ≤ t ≤ ti) in constant flow mechanical ventilation to ventilator-induced lung injury. They have correlated b with low-volume stress (b ≤ 0.9), high-volume stress (b ≥ 1.1), and minimal stress (0.9 ≤ b ≤ 1.1) in the lungs. In this paper we examine the theoretical underpinnings of this empirical equation and show that it has a relationship to the upper and lower inflection points of the Pelastic - V curve during inspiration. An alternative equation (Paw(t) ≈ αt/γ+βt + Λ) that comes from the theoretical analysis of this type of mechanical ventilation is presented. Both equations are compared using experimental data.

Original languageEnglish (US)
Pages (from-to)261-272
Number of pages12
JournalJournal of Biological Systems
Issue number3
StatePublished - Sep 2005
Externally publishedYes


  • Lung Injury
  • Mathematical Model
  • Stress Index
  • Variable Compliance


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