A new look at dry eye disease and its treatment

J. Daniel Nelson, Harold Helms, Richard Fiscella, Yvonne Southwell, Jan D. Hirsch

Research output: Contribution to journalReview articlepeer-review

82 Scopus citations


This review examines the impact of moderate to severe dry eye disease on daily life and medical-resource utilization. The results suggest that current treatment paradigms can lead to unacceptable costs in both quality of life and progressive use of healthcare resources. Evidence linking this disease to T-cell-mediated inflammatory processes lays the foundation for understanding the clinical benefits of topical cyclosporine, an immunomodulatory and anti- inflammatory agent.

Original languageEnglish (US)
Pages (from-to)84-93
Number of pages10
JournalAdvances in Therapy
Issue number2
StatePublished - 2000
Externally publishedYes


  • Cyclosporine
  • Dry eye
  • Inflammatory response


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