A new heart: Somatic stem cells and myocardial regeneration

Philip S. Mullenix, Steven J. Huddleston, Alexander Stojadinovic, Gregory D. Trachiotis, Edmund P. Alexander

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

End-stage heart failure is a global scourge. Current therapies merely delay its inexorable progression. Heart transplantation is resource-intensive and limited by organ availability. Bone marrow-derived and cardiac-specific stem cells have demonstrated potential for cardiac regeneration and repair, but the magnitude and durability of these promising findings are inconsistent. The purpose of this review is to (1) describe cells currently being investigated, (2) outline the status of current trials, and (3) discuss key objectives of future research.

Original languageEnglish (US)
Pages (from-to)475-480
Number of pages6
JournalJournal of Surgical Oncology
Volume105
Issue number5
DOIs
StatePublished - Apr 1 2012

Keywords

  • heart failure
  • myocardial infarction
  • myocardial regeneration
  • somatic stem cells

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