TY - JOUR
T1 - A new heart
T2 - Somatic stem cells and myocardial regeneration
AU - Mullenix, Philip S.
AU - Huddleston, Steven J.
AU - Stojadinovic, Alexander
AU - Trachiotis, Gregory D.
AU - Alexander, Edmund P.
PY - 2012/4/1
Y1 - 2012/4/1
N2 - End-stage heart failure is a global scourge. Current therapies merely delay its inexorable progression. Heart transplantation is resource-intensive and limited by organ availability. Bone marrow-derived and cardiac-specific stem cells have demonstrated potential for cardiac regeneration and repair, but the magnitude and durability of these promising findings are inconsistent. The purpose of this review is to (1) describe cells currently being investigated, (2) outline the status of current trials, and (3) discuss key objectives of future research.
AB - End-stage heart failure is a global scourge. Current therapies merely delay its inexorable progression. Heart transplantation is resource-intensive and limited by organ availability. Bone marrow-derived and cardiac-specific stem cells have demonstrated potential for cardiac regeneration and repair, but the magnitude and durability of these promising findings are inconsistent. The purpose of this review is to (1) describe cells currently being investigated, (2) outline the status of current trials, and (3) discuss key objectives of future research.
KW - heart failure
KW - myocardial infarction
KW - myocardial regeneration
KW - somatic stem cells
UR - http://www.scopus.com/inward/record.url?scp=84859037504&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84859037504&partnerID=8YFLogxK
U2 - 10.1002/jso.23014
DO - 10.1002/jso.23014
M3 - Review article
C2 - 22441899
AN - SCOPUS:84859037504
SN - 0022-4790
VL - 105
SP - 475
EP - 480
JO - Journal of Surgical Oncology
JF - Journal of Surgical Oncology
IS - 5
ER -
