A new fluoridolysable anchoring linkage for orthogonal solid-phase peptide synthesis: Preparation and properties of the N-(3 or 4)-[[[(4-hydroxymethyl)-phenoxy-t-butylphenyl]silyl]phenyl]pentanedioic acid, monoamide (PBS) handle

Daniel G. Mullen, George Barany

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

The synthesis and characterization of a new silicon-containing handle for use in solid-phase peptide synthesis is described. The anchoring linkage derived from this new handle, when treated with fluoride (1.0 equiv.) for 5 min at 25 °C, releases peptides as their free acids in essentially quantitative yields and without racemization.

Original languageEnglish (US)
Pages (from-to)491-494
Number of pages4
JournalTetrahedron Letters
Volume28
Issue number5
DOIs
StatePublished - 1987

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