A new era for improving cardiothoracic transplantations

Andrew W. Shaffer, Lars M. Mattison, John R. Spratt, Tinen L. Iles, Natalie Kerns, Michael G. Bateman, Stephen J. Huddleston, Rosemary F. Kelly, Ranjit John, Kenneth K. Liao, Paul A. Iaizzo

Research output: Chapter in Book/Report/Conference proceedingChapter


Cardiothoracic transplantation research dates back to the late 1800s, yet the first human heart transplantation did not occur until 1967. Today, more and more centers worldwide are performing such procedures with increasing success, long-term survival rates, and, importantly, with an improved quality of life for recipients. Much work remains to increase the number of available hearts and lungs for these transplants, but progress is being made for many reasons that are discussed in this chapter. The use of ex vivo lung and heart perfusion technologies along with pharmacological advancements (e.g., preservation solutions) has expanded the time available between organ recovery and transplantation, allowing for enhanced functional assessment and providing a platform for therapeutic delivery. In this chapter, we provide a brief history of cardiothoracic transplantation, review the current state of transplantation procedures, and discuss future directions for research and technological advancements.

Original languageEnglish (US)
Title of host publicationEngineering in Medicine
Subtitle of host publicationAdvances and Challenges
Number of pages28
ISBN (Electronic)9780128130681
ISBN (Print)9780128135143
StatePublished - Jan 1 2018


  • Donation after cardiac death (DCD)
  • EXPAND Heart trial
  • End-stage heart failure
  • Ex vivo perfusion
  • Heart transplantation
  • INSPIRE trial
  • Lung transplantation
  • Organ donation
  • PROCEED II trial
  • REVIVE trial


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