A new and facile route for the synthesis of chiral 1,2-diamines and 2,3-diamino acids

Upender K. Nadir; R. Vijaya Krishna; Anamika Singh

doi:10.1016/j.tetlet.2004.11.088

A new and facile route for the synthesis of chiral 1,2-diamines and 2,3-diamino acids

Upender K. Nadir, R. Vijaya Krishna, Anamika Singh

Medicinal Chemistry

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

The synthesis of chiral diamines and diamino acids has been achieved from the corresponding N-arylsulfonyl aziridines through reaction with a chiral isocyanate and subsequent hydrolysis of 2-imidazolidinones. The method appears to be general and of wide applicability.

Original language	English (US)
Pages (from-to)	479-482
Number of pages	4
Journal	Tetrahedron Letters
Volume	46
Issue number	3
DOIs	https://doi.org/10.1016/j.tetlet.2004.11.088
State	Published - Jan 17 2005

Bibliographical note

Funding Information:
We thank the Council of Scientific and Industrial Research (CSIR), New Delhi for financial support of this work and fellowships to R.V.K. and A.S. Thanks are also due to Dr. A. Ramanan and Shailesh Upreti for X-ray crystal data.

Keywords

2-Imidazolidinones
Diamines
Diamino acids

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10.1016/j.tetlet.2004.11.088

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title = "A new and facile route for the synthesis of chiral 1,2-diamines and 2,3-diamino acids",

abstract = "The synthesis of chiral diamines and diamino acids has been achieved from the corresponding N-arylsulfonyl aziridines through reaction with a chiral isocyanate and subsequent hydrolysis of 2-imidazolidinones. The method appears to be general and of wide applicability.",

keywords = "2-Imidazolidinones, Diamines, Diamino acids",

author = "Nadir, \{Upender K.\} and Krishna, \{R. Vijaya\} and Anamika Singh",

note = "Funding Information: We thank the Council of Scientific and Industrial Research (CSIR), New Delhi for financial support of this work and fellowships to R.V.K. and A.S. Thanks are also due to Dr. A. Ramanan and Shailesh Upreti for X-ray crystal data. ",

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T1 - A new and facile route for the synthesis of chiral 1,2-diamines and 2,3-diamino acids

AU - Nadir, Upender K.

AU - Krishna, R. Vijaya

AU - Singh, Anamika

N1 - Funding Information: We thank the Council of Scientific and Industrial Research (CSIR), New Delhi for financial support of this work and fellowships to R.V.K. and A.S. Thanks are also due to Dr. A. Ramanan and Shailesh Upreti for X-ray crystal data.

PY - 2005/1/17

Y1 - 2005/1/17

N2 - The synthesis of chiral diamines and diamino acids has been achieved from the corresponding N-arylsulfonyl aziridines through reaction with a chiral isocyanate and subsequent hydrolysis of 2-imidazolidinones. The method appears to be general and of wide applicability.

AB - The synthesis of chiral diamines and diamino acids has been achieved from the corresponding N-arylsulfonyl aziridines through reaction with a chiral isocyanate and subsequent hydrolysis of 2-imidazolidinones. The method appears to be general and of wide applicability.

KW - 2-Imidazolidinones

KW - Diamines

KW - Diamino acids

UR - https://www.scopus.com/pages/publications/11144321279

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U2 - 10.1016/j.tetlet.2004.11.088

DO - 10.1016/j.tetlet.2004.11.088

M3 - Article

AN - SCOPUS:11144321279

SN - 0040-4039

VL - 46

SP - 479

EP - 482

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 3

ER -

A new and facile route for the synthesis of chiral 1,2-diamines and 2,3-diamino acids

Abstract

Bibliographical note

Keywords

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