A new and facile route for the synthesis of chiral 1,2-diamines and 2,3-diamino acids

Upender K. Nadir, R. Vijaya Krishna, Anamika Singh

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29 Scopus citations

Abstract

The synthesis of chiral diamines and diamino acids has been achieved from the corresponding N-arylsulfonyl aziridines through reaction with a chiral isocyanate and subsequent hydrolysis of 2-imidazolidinones. The method appears to be general and of wide applicability.

Original languageEnglish (US)
Pages (from-to)479-482
Number of pages4
JournalTetrahedron Letters
Volume46
Issue number3
DOIs
StatePublished - Jan 17 2005

Bibliographical note

Funding Information:
We thank the Council of Scientific and Industrial Research (CSIR), New Delhi for financial support of this work and fellowships to R.V.K. and A.S. Thanks are also due to Dr. A. Ramanan and Shailesh Upreti for X-ray crystal data.

Keywords

  • 2-Imidazolidinones
  • Diamines
  • Diamino acids

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