The synthesis of chiral diamines and diamino acids has been achieved from the corresponding N-arylsulfonyl aziridines through reaction with a chiral isocyanate and subsequent hydrolysis of 2-imidazolidinones. The method appears to be general and of wide applicability.
Bibliographical noteFunding Information:
We thank the Council of Scientific and Industrial Research (CSIR), New Delhi for financial support of this work and fellowships to R.V.K. and A.S. Thanks are also due to Dr. A. Ramanan and Shailesh Upreti for X-ray crystal data.
- Diamino acids