A neurodevelopmental perspective on the acquisition of nonverbal cognitive skills in adolescents with fragile X syndrome

Sara T. Kover, Elizabeth I. Pierpont, Jee Seon Kim, W. Ted Brown, Leonard Abbeduto

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

This longitudinal study was designed to investigate trajectories of nonverbal cognitive ability in adolescents with fragile X syndrome with respect to the relative influence of fragile X mental retardation protein (FMRP), autism symptom severity, and environmental factors on visualization and fluid reasoning abilities. Males and females with fragile X syndrome (N = 53; ages 10-16 years) were evaluated with the Leiter-R at up to four annual assessments. On average, IQ declined with age. FMRP levels predicted change in fluid reasoning, but not in visualization. The role of FMRP in the neural development that underlies the fragile X syndrome cognitive phenotype is discussed.

Original languageEnglish (US)
Pages (from-to)445-460
Number of pages16
JournalDevelopmental Neuropsychology
Volume38
Issue number7
DOIs
StatePublished - Oct 1 2013

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