A nanoparticle dispersion method for in vitro and in vivo nanotoxicity study

Seong C. Kim, Da Ren Chen, Chaolong Qi, Robert M. Gelein, Jacob N. Finkelstein, Alison Elder, Karen Bentley, Günter Oberdörster, David Y.H. Pui

Research output: Contribution to journalArticle

50 Citations (Scopus)

Abstract

The dispersion in air of nanoparticles of different sizes, materials and morphologies with controlled agglomeration involving aerosol delivery for in vivo and in vitro studies is one of the most difficult challenges in the field of nanoparticle toxicology. We describe here a nanoparticle dispersion system using an electrospray method to deliver airborne nanoparticles (∼ 10-100 nm) with spatial uniformity and controllable particle concentration for in vitro and in vivo studies. With the dispersion method, single nanoparticles (polystyrene latex particles, TiO2, Au, Mn, quantum dots, and carbon nanotubes) can be delivered to cells and animals via the air. The degree of agglomeration can be controlled by changing the suspension feeding rate to simulate realistic conditions for exposure studies.

Original languageEnglish (US)
Pages (from-to)42-51
Number of pages10
JournalNanotoxicology
Volume4
Issue number1
DOIs
StatePublished - Mar 1 2010

Fingerprint

Nanoparticles
Agglomeration
Air
Quantum Dots
Carbon Nanotubes
Aerosols
Latexes
Microspheres
Toxicology
Particles (particulate matter)
Semiconductor quantum dots
Carbon nanotubes
Polystyrenes
Suspensions
Animals
In Vitro Techniques

Keywords

  • Aerosols
  • Electrospray
  • In vitro
  • In vivo
  • Nanoparticles
  • Toxicology

Cite this

A nanoparticle dispersion method for in vitro and in vivo nanotoxicity study. / Kim, Seong C.; Chen, Da Ren; Qi, Chaolong; Gelein, Robert M.; Finkelstein, Jacob N.; Elder, Alison; Bentley, Karen; Oberdörster, Günter; Pui, David Y.H.

In: Nanotoxicology, Vol. 4, No. 1, 01.03.2010, p. 42-51.

Research output: Contribution to journalArticle

Kim, SC, Chen, DR, Qi, C, Gelein, RM, Finkelstein, JN, Elder, A, Bentley, K, Oberdörster, G & Pui, DYH 2010, 'A nanoparticle dispersion method for in vitro and in vivo nanotoxicity study', Nanotoxicology, vol. 4, no. 1, pp. 42-51. https://doi.org/10.3109/17435390903374019
Kim, Seong C. ; Chen, Da Ren ; Qi, Chaolong ; Gelein, Robert M. ; Finkelstein, Jacob N. ; Elder, Alison ; Bentley, Karen ; Oberdörster, Günter ; Pui, David Y.H. / A nanoparticle dispersion method for in vitro and in vivo nanotoxicity study. In: Nanotoxicology. 2010 ; Vol. 4, No. 1. pp. 42-51.
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