A multivariate model for the analysis of sibship covariance structure using marker information and multiple quantitative traits

George P. Vogler, Weihong Tang, Tracy L. Nelson, Scott M. Hofer, Julia D. Grant, Lisa M. Tarantino, Jose R. Fernandez

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

A model was developed to detect effects of quantitative trait loci (QTLs) in sibships from simulated nuclear family data using full covariance structure of the data and analyzing all five quantitative traits simultaneously in a multivariate model. Evidence of the presence of loci was detected on chromosomes 4,8,9, and 10. The method provided stable results and is worth further exploration for its performance and optimal sample size requirements under realistic conditions.

Original languageEnglish (US)
Pages (from-to)921-926
Number of pages6
JournalGenetic epidemiology
Volume14
Issue number6
DOIs
StatePublished - 1997

Keywords

  • Multivariate
  • Power
  • QTL
  • Sibships

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