Patients with repaired tetralogy of Fallot account for the majority of cases with late onset right ventricle (RV) failure. A new surgical procedure placing an elastic band in the right ventricle is proposed to improve RV function measured by ejection fraction. A multiphysics modeling approach is developed to combine cardiac magnetic resonance imaging, modeling, tissue engineering and mechanical testing to demonstrate feasibility of the new surgical procedure. Our modeling results indicated that the new surgical procedure has the potential to improve right ventricle ejection fraction by 2-7% which compared favorably with recently published drug trials to treat LV heart failure.
Bibliographical noteFunding Information:
This research was supported in part by NIH-1R01-HL 089269 (del Nido, Tang, Geva), NIH–HL63095 (PI: del Nido) and NIH-NHLBI 5P50HL074734 (PI: Geva; Co-Investigator: del Nido). Chun Yang’s research is supported in part by National Sciences Foundation of China 11171030 and the Fundamental Research Funds for the Central Universities .
- Congenital heart disease
- Fluid-structural interaction
- Heart model
- Pulmonary valve replacement
- Right ventricle