A multiphysics modeling approach to develop right ventricle pulmonary valve replacement surgical procedures with a contracting band to improve ventricle ejection fraction

Dalin Tang, Chun Yang, Tal Geva, Rahul Rathod, Haruo Yamauchi, Vasu Gooty, Alexander Tang, Mehmet H. Kural, Kristen L. Billiar, Glenn Gaudette, Pedro J. Del Nido

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Patients with repaired tetralogy of Fallot account for the majority of cases with late onset right ventricle (RV) failure. A new surgical procedure placing an elastic band in the right ventricle is proposed to improve RV function measured by ejection fraction. A multiphysics modeling approach is developed to combine cardiac magnetic resonance imaging, modeling, tissue engineering and mechanical testing to demonstrate feasibility of the new surgical procedure. Our modeling results indicated that the new surgical procedure has the potential to improve right ventricle ejection fraction by 2-7% which compared favorably with recently published drug trials to treat LV heart failure.

Original languageEnglish (US)
Pages (from-to)78-87
Number of pages10
JournalComputers and Structures
Volume122
DOIs
StatePublished - 2013

Bibliographical note

Funding Information:
This research was supported in part by NIH-1R01-HL 089269 (del Nido, Tang, Geva), NIH–HL63095 (PI: del Nido) and NIH-NHLBI 5P50HL074734 (PI: Geva; Co-Investigator: del Nido). Chun Yang’s research is supported in part by National Sciences Foundation of China 11171030 and the Fundamental Research Funds for the Central Universities .

Keywords

  • Congenital heart disease
  • Fluid-structural interaction
  • Heart model
  • Multiscale
  • Pulmonary valve replacement
  • Right ventricle

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