A multicenter study of total pancreatectomy with islet autotransplantation (TPIAT): POST (Prospective Observational Study of TPIAT)

POST study consortium

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background/objectives: Total pancreatectomy with islet autotransplantation (TPIAT) is considered for managing chronic pancreatitis in selected patients when medical and endoscopic interventions have not provided adequate relief from debilitating pain. Although more centers are performing TPIAT, we lack large, multi-center studies to guide decisions about selecting candidates for and timing of TPIAT. Methods: Multiple centers across the United States (9 to date) performing TPIAT are prospectively enrolling patients undergoing TPIAT for chronic pancreatitis into the Prospective Observational Study of TPIAT (POST), a NIDDK funded study with a goal of accruing 450 TPIAT recipients. Baseline data include participant phenotype, pancreatitis history, and medical/psychological comorbidities from medical records, participant interview, and participant self-report (Medical Outcomes Survey Short Form-12, EQ-5D, andPROMIS inventories for pain interference, depression, and anxiety). Outcome measures are collected to at least 1 year after TPIAT, including the same participant questionnaires, visual analog pain scale, pain interference scores, opioid requirements, insulin requirements, islet graft function, and hemoglobin A1c. Health resource utilization data are collected for a cost-effectiveness analysis. Biorepository specimens including urine, serum/plasma, genetic material (saliva and blood), and pancreas tissue are collected for future study. Conclusions: This ongoing multicenter research study will enroll and follow TPIAT recipients, aiming to evaluate patient selection and timing for TPIAT to optimize pain relief, quality of life, and diabetes outcomes, and to measure the procedure's cost-effectiveness. A biorepository is also established for future ancillary studies.

Original languageEnglish (US)
Pages (from-to)286-290
Number of pages5
JournalPancreatology
Volume18
Issue number3
DOIs
StatePublished - Apr 1 2018

Fingerprint

Pancreatectomy
Autologous Transplantation
Multicenter Studies
Observational Studies
Prospective Studies
Pain
Chronic Pancreatitis
Cost-Benefit Analysis
National Institute of Diabetes and Digestive and Kidney Diseases (U.S.)
Outcome Assessment (Health Care)
Health Resources
Pain Measurement
Saliva
Pancreatitis
Self Report
Patient Selection
Opioid Analgesics
Medical Records
Comorbidity
Pancreas

Keywords

  • Diabetes
  • Islet
  • Pain
  • Pancreatitis
  • Total pancreatectomy

PubMed: MeSH publication types

  • Journal Article
  • Multicenter Study
  • Observational Study

Cite this

A multicenter study of total pancreatectomy with islet autotransplantation (TPIAT) : POST (Prospective Observational Study of TPIAT). / POST study consortium.

In: Pancreatology, Vol. 18, No. 3, 01.04.2018, p. 286-290.

Research output: Contribution to journalArticle

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title = "A multicenter study of total pancreatectomy with islet autotransplantation (TPIAT): POST (Prospective Observational Study of TPIAT)",
abstract = "Background/objectives: Total pancreatectomy with islet autotransplantation (TPIAT) is considered for managing chronic pancreatitis in selected patients when medical and endoscopic interventions have not provided adequate relief from debilitating pain. Although more centers are performing TPIAT, we lack large, multi-center studies to guide decisions about selecting candidates for and timing of TPIAT. Methods: Multiple centers across the United States (9 to date) performing TPIAT are prospectively enrolling patients undergoing TPIAT for chronic pancreatitis into the Prospective Observational Study of TPIAT (POST), a NIDDK funded study with a goal of accruing 450 TPIAT recipients. Baseline data include participant phenotype, pancreatitis history, and medical/psychological comorbidities from medical records, participant interview, and participant self-report (Medical Outcomes Survey Short Form-12, EQ-5D, andPROMIS inventories for pain interference, depression, and anxiety). Outcome measures are collected to at least 1 year after TPIAT, including the same participant questionnaires, visual analog pain scale, pain interference scores, opioid requirements, insulin requirements, islet graft function, and hemoglobin A1c. Health resource utilization data are collected for a cost-effectiveness analysis. Biorepository specimens including urine, serum/plasma, genetic material (saliva and blood), and pancreas tissue are collected for future study. Conclusions: This ongoing multicenter research study will enroll and follow TPIAT recipients, aiming to evaluate patient selection and timing for TPIAT to optimize pain relief, quality of life, and diabetes outcomes, and to measure the procedure's cost-effectiveness. A biorepository is also established for future ancillary studies.",
keywords = "Diabetes, Islet, Pain, Pancreatitis, Total pancreatectomy",
author = "{POST study consortium} and Bellin, {Melena D} and Maisam Abu-El-Haija and Katherine Morgan and David Adams and Beilman, {Gregory J} and Srinath Chinnakotla and Conwell, {Darwin L.} and Dunn, {Ty B.} and Freeman, {Martin L} and Timothy Gardner and Varvara Kirchner and Lara, {Luis F.} and Leslie Long-Simpson and Nathan, {Jaimie D.} and Bashoo Naziruddin and Nyman, {John A} and Pruett, {Timothy L} and Schwarzenberg, {Sarah J} and Singh, {Vikesh K.} and Kerrington Smith and Steel, {Jennifer L.} and Martin Wijkstrom and Piotr Witkowski and Hodges, {James S}",
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T2 - POST (Prospective Observational Study of TPIAT)

AU - POST study consortium

AU - Bellin, Melena D

AU - Abu-El-Haija, Maisam

AU - Morgan, Katherine

AU - Adams, David

AU - Beilman, Gregory J

AU - Chinnakotla, Srinath

AU - Conwell, Darwin L.

AU - Dunn, Ty B.

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AU - Kirchner, Varvara

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AU - Nathan, Jaimie D.

AU - Naziruddin, Bashoo

AU - Nyman, John A

AU - Pruett, Timothy L

AU - Schwarzenberg, Sarah J

AU - Singh, Vikesh K.

AU - Smith, Kerrington

AU - Steel, Jennifer L.

AU - Wijkstrom, Martin

AU - Witkowski, Piotr

AU - Hodges, James S

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N2 - Background/objectives: Total pancreatectomy with islet autotransplantation (TPIAT) is considered for managing chronic pancreatitis in selected patients when medical and endoscopic interventions have not provided adequate relief from debilitating pain. Although more centers are performing TPIAT, we lack large, multi-center studies to guide decisions about selecting candidates for and timing of TPIAT. Methods: Multiple centers across the United States (9 to date) performing TPIAT are prospectively enrolling patients undergoing TPIAT for chronic pancreatitis into the Prospective Observational Study of TPIAT (POST), a NIDDK funded study with a goal of accruing 450 TPIAT recipients. Baseline data include participant phenotype, pancreatitis history, and medical/psychological comorbidities from medical records, participant interview, and participant self-report (Medical Outcomes Survey Short Form-12, EQ-5D, andPROMIS inventories for pain interference, depression, and anxiety). Outcome measures are collected to at least 1 year after TPIAT, including the same participant questionnaires, visual analog pain scale, pain interference scores, opioid requirements, insulin requirements, islet graft function, and hemoglobin A1c. Health resource utilization data are collected for a cost-effectiveness analysis. Biorepository specimens including urine, serum/plasma, genetic material (saliva and blood), and pancreas tissue are collected for future study. Conclusions: This ongoing multicenter research study will enroll and follow TPIAT recipients, aiming to evaluate patient selection and timing for TPIAT to optimize pain relief, quality of life, and diabetes outcomes, and to measure the procedure's cost-effectiveness. A biorepository is also established for future ancillary studies.

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KW - Islet

KW - Pain

KW - Pancreatitis

KW - Total pancreatectomy

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