A multi-time-scale analysis of chemical reaction networks: I. Deterministic systems

Chang Hyeong Lee, Hans G. Othmer

Research output: Contribution to journalArticlepeer-review

48 Scopus citations


We consider deterministic descriptions of reaction networks in which different reactions occur on at least two distinct time scales. We show that when a certain Jacobian is nonsingular there is a coordinate system in which the evolution equations for slow and fast variables are separated, and we obtain the appropriate initial conditions for the transformed system. We also discuss topological properties which guarantee that the nonsingularity condition is satisfied, and show that in the new coordinate frame the evolution of the slow variables on the slow time scale is independent of the fast variables to lowest order in a small parameter. Several examples that illustrate the numerical accuracy of the reduction are presented, and an extension of the reduction method to three or more time scale networks is discussed.

Original languageEnglish (US)
Pages (from-to)387-450
Number of pages64
JournalJournal of Mathematical Biology
Issue number3
StatePublished - Sep 2010


  • Chemical reaction networks
  • Multi-time-scale analysis
  • Reduction of graph of reaction networks


Dive into the research topics of 'A multi-time-scale analysis of chemical reaction networks: I. Deterministic systems'. Together they form a unique fingerprint.

Cite this