A multi-modal parcellation of human cerebral cortex

Matthew F. Glasser, Timothy S. Coalson, Emma C. Robinson, Carl D. Hacker, John Harwell, Essa Yacoub, Kamil Ugurbil, Jesper Andersson, Christian F. Beckmann, Mark Jenkinson, Stephen M. Smith, David C. Van Essen

Research output: Contribution to journalArticle

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Abstract

Understanding the amazingly complex human cerebral cortex requires a map (or parcellation) of its major subdivisions, known as cortical areas. Making an accurate areal map has been a century-old objective in neuroscience. Using multi-modal magnetic resonance images from the Human Connectome Project (HCP) and an objective semi-automated neuroanatomical approach, we delineated 180 areas per hemisphere bounded by sharp changes in cortical architecture, function, connectivity, and/or topography in a precisely aligned group average of 210 healthy young adults. We characterized 97 new areas and 83 areas previously reported using post-mortem microscopy or other specialized study-specific approaches. To enable automated delineation and identification of these areas in new HCP subjects and in future studies, we trained a machine-learning classifier to recognize the multi-modal 'fingerprint' of each cortical area. This classifier detected the presence of 96.6% of the cortical areas in new subjects, replicated the group parcellation, and could correctly locate areas in individuals with atypical parcellations. The freely available parcellation and classifier will enable substantially improved neuroanatomical precision for studies of the structural and functional organization of human cerebral cortex and its variation across individuals and in development, aging, and disease.

Original languageEnglish (US)
Pages (from-to)171-178
Number of pages8
JournalNature
Volume536
Issue number7615
DOIs
StatePublished - Aug 3 2016

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Connectome
Cerebral Cortex
Dermatoglyphics
Neurosciences
Young Adult
Microscopy
Magnetic Resonance Spectroscopy

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Glasser, M. F., Coalson, T. S., Robinson, E. C., Hacker, C. D., Harwell, J., Yacoub, E., ... Van Essen, D. C. (2016). A multi-modal parcellation of human cerebral cortex. Nature, 536(7615), 171-178. https://doi.org/10.1038/nature18933

A multi-modal parcellation of human cerebral cortex. / Glasser, Matthew F.; Coalson, Timothy S.; Robinson, Emma C.; Hacker, Carl D.; Harwell, John; Yacoub, Essa; Ugurbil, Kamil; Andersson, Jesper; Beckmann, Christian F.; Jenkinson, Mark; Smith, Stephen M.; Van Essen, David C.

In: Nature, Vol. 536, No. 7615, 03.08.2016, p. 171-178.

Research output: Contribution to journalArticle

Glasser, MF, Coalson, TS, Robinson, EC, Hacker, CD, Harwell, J, Yacoub, E, Ugurbil, K, Andersson, J, Beckmann, CF, Jenkinson, M, Smith, SM & Van Essen, DC 2016, 'A multi-modal parcellation of human cerebral cortex', Nature, vol. 536, no. 7615, pp. 171-178. https://doi.org/10.1038/nature18933
Glasser MF, Coalson TS, Robinson EC, Hacker CD, Harwell J, Yacoub E et al. A multi-modal parcellation of human cerebral cortex. Nature. 2016 Aug 3;536(7615):171-178. https://doi.org/10.1038/nature18933
Glasser, Matthew F. ; Coalson, Timothy S. ; Robinson, Emma C. ; Hacker, Carl D. ; Harwell, John ; Yacoub, Essa ; Ugurbil, Kamil ; Andersson, Jesper ; Beckmann, Christian F. ; Jenkinson, Mark ; Smith, Stephen M. ; Van Essen, David C. / A multi-modal parcellation of human cerebral cortex. In: Nature. 2016 ; Vol. 536, No. 7615. pp. 171-178.
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