A Multi-Cohort Examination of the Independent Contributions of Maternal Childhood Adversity and Pregnancy Stressors to the Prediction of Children’s Anxiety and Depression

Amanda Noroña-Zhou; Michael Coccia; Alexis Sullivan; Thomas G. O’Connor; Brent R. Collett; Karen Derefinko; Lynette M. Renner; Christine T. Loftus; Danielle Roubinov; Kecia N. Carroll; Ruby H.N. Nguyen; Catherine J. Karr; Sheela Sathyanarayana; Emily S. Barrett; W. Alex Mason; Kaja Z. LeWinn; Nicole R. Bush

doi:10.1007/s10802-022-01002-3

A Multi-Cohort Examination of the Independent Contributions of Maternal Childhood Adversity and Pregnancy Stressors to the Prediction of Children’s Anxiety and Depression

Amanda Noroña-Zhou, Michael Coccia, Alexis Sullivan, Thomas G. O’Connor, Brent R. Collett, Karen Derefinko, Lynette M. Renner, Christine T. Loftus, Danielle Roubinov, Kecia N. Carroll, Ruby H.N. Nguyen, Catherine J. Karr, Sheela Sathyanarayana, Emily S. Barrett, W. Alex Mason, Kaja Z. LeWinn, Nicole R. Bush

Research output: Contribution to journal › Article › peer-review

Abstract

Women’s social experiences can have long-term implications for their offspring’s health, but little is known about the potential independent contributions of multiple periods of stress exposures over time. This study examined associations of maternal exposure to adversity in childhood and pregnancy with children’s anxiety and depression symptoms in a large, sociodemographically diverse sample. Participants were 1389 mother-child dyads (child age M = 8.83 years; SD = 0.66; 42% Black, 42% White; 6% Hispanic) in the ECHO-PATHWAYS Consortium’s three U.S. pregnancy cohorts. Women reported their exposure to childhood traumatic events (CTE) and pregnancy stressful life events (PSLE). Children self-reported on their symptoms of anxiety and depression at age 8–9 years. Regression analyses estimated associations between maternal stressors and children’s internalizing problems, adjusting for confounders, and examined child sex as a modifier. Exploratory interaction analyses examined whether geospatially-linked postnatal neighborhood quality buffered effects. In adjusted models, PSLE counts positively predicted levels of children’s anxiety and depression symptoms ([ß_Anxiety=0.08, 95%CI [0.02, 0.13]; ß_Depression=0.09, 95%CI [0.03, 0.14]); no significant associations were observed with CTE. Each additional PSLE increased odds of clinically significant anxiety symptoms by 9% (95%CI [0.02, 0.17]). Neither sex nor neighborhood quality moderated relations. Maternal stressors during pregnancy appear to have associations with middle childhood anxiety and depression across diverse sociodemographic contexts, whereas maternal history of childhood adversity may not. Effects appear comparable for boys and girls. Policies and programs addressing prevention of childhood internalizing symptoms may benefit from considering prenatal origins and the potential two-generation impact of pregnancy stress prevention and intervention.

Original language	English (US)
Pages (from-to)	497-512
Number of pages	16
Journal	Research on Child and Adolescent Psychopathology
Volume	51
Issue number	4
DOIs	https://doi.org/10.1007/s10802-022-01002-3
State	Published - Apr 2023

Bibliographical note

Funding Information:
This study was supported by the NIH ECHO program (NIH UG3/UH3OD023271 and UG3/UH3OD023305), NIEHS (1R01ES25169, R01ES016863, P30ES005022, P30ES007033), NHLBI (1R01 HL132338), NCATS (UL1 TR002319), the Urban Child Institute, and the Lisa Stone Pritzker Family Foundation. This three-cohort work could not be conducted without the incredible study staff, data teams, and co-investigators on the three cohorts and PATHWAYS award team, and we are grateful for their efforts as well as the generous contributions of participating women and children over the past decade. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This manuscript has been reviewed by PATHWAYS for scientific content and consistency of data interpretation with previous PATHWAYS publications.

Publisher Copyright:
© 2022, The Author(s).

Keywords

Child anxiety
Child depression
Childhood trauma
Intergenerational transmission
Pregnancy stress

PubMed: MeSH publication types

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Publisher link

10.1007/s10802-022-01002-3

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Noroña-Zhou, A., Coccia, M., Sullivan, A., O’Connor, T. G., Collett, B. R., Derefinko, K., Renner, L. M., Loftus, C. T., Roubinov, D., Carroll, K. N., Nguyen, R. H. N., Karr, C. J., Sathyanarayana, S., Barrett, E. S., Mason, W. A., LeWinn, K. Z., & Bush, N. R. (2023). A Multi-Cohort Examination of the Independent Contributions of Maternal Childhood Adversity and Pregnancy Stressors to the Prediction of Children’s Anxiety and Depression. Research on Child and Adolescent Psychopathology, 51(4), 497-512. https://doi.org/10.1007/s10802-022-01002-3

A Multi-Cohort Examination of the Independent Contributions of Maternal Childhood Adversity and Pregnancy Stressors to the Prediction of Children’s Anxiety and Depression. / Noroña-Zhou, Amanda; Coccia, Michael; Sullivan, Alexis et al.
In: Research on Child and Adolescent Psychopathology, Vol. 51, No. 4, 04.2023, p. 497-512.

Research output: Contribution to journal › Article › peer-review

Noroña-Zhou, A, Coccia, M, Sullivan, A, O’Connor, TG, Collett, BR, Derefinko, K, Renner, LM, Loftus, CT, Roubinov, D, Carroll, KN, Nguyen, RHN, Karr, CJ, Sathyanarayana, S, Barrett, ES, Mason, WA, LeWinn, KZ & Bush, NR 2023, 'A Multi-Cohort Examination of the Independent Contributions of Maternal Childhood Adversity and Pregnancy Stressors to the Prediction of Children’s Anxiety and Depression', Research on Child and Adolescent Psychopathology, vol. 51, no. 4, pp. 497-512. https://doi.org/10.1007/s10802-022-01002-3

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abstract = "Women{\textquoteright}s social experiences can have long-term implications for their offspring{\textquoteright}s health, but little is known about the potential independent contributions of multiple periods of stress exposures over time. This study examined associations of maternal exposure to adversity in childhood and pregnancy with children{\textquoteright}s anxiety and depression symptoms in a large, sociodemographically diverse sample. Participants were 1389 mother-child dyads (child age M = 8.83 years; SD = 0.66; 42% Black, 42% White; 6% Hispanic) in the ECHO-PATHWAYS Consortium{\textquoteright}s three U.S. pregnancy cohorts. Women reported their exposure to childhood traumatic events (CTE) and pregnancy stressful life events (PSLE). Children self-reported on their symptoms of anxiety and depression at age 8–9 years. Regression analyses estimated associations between maternal stressors and children{\textquoteright}s internalizing problems, adjusting for confounders, and examined child sex as a modifier. Exploratory interaction analyses examined whether geospatially-linked postnatal neighborhood quality buffered effects. In adjusted models, PSLE counts positively predicted levels of children{\textquoteright}s anxiety and depression symptoms ([{\ss}Anxiety=0.08, 95%CI [0.02, 0.13]; {\ss}Depression=0.09, 95%CI [0.03, 0.14]); no significant associations were observed with CTE. Each additional PSLE increased odds of clinically significant anxiety symptoms by 9% (95%CI [0.02, 0.17]). Neither sex nor neighborhood quality moderated relations. Maternal stressors during pregnancy appear to have associations with middle childhood anxiety and depression across diverse sociodemographic contexts, whereas maternal history of childhood adversity may not. Effects appear comparable for boys and girls. Policies and programs addressing prevention of childhood internalizing symptoms may benefit from considering prenatal origins and the potential two-generation impact of pregnancy stress prevention and intervention.",

keywords = "Child anxiety, Child depression, Childhood trauma, Intergenerational transmission, Pregnancy stress",

author = "Amanda Noro{\~n}a-Zhou and Michael Coccia and Alexis Sullivan and O{\textquoteright}Connor, {Thomas G.} and Collett, {Brent R.} and Karen Derefinko and Renner, {Lynette M.} and Loftus, {Christine T.} and Danielle Roubinov and Carroll, {Kecia N.} and Nguyen, {Ruby H.N.} and Karr, {Catherine J.} and Sheela Sathyanarayana and Barrett, {Emily S.} and Mason, {W. Alex} and LeWinn, {Kaja Z.} and Bush, {Nicole R.}",

note = "Funding Information: This study was supported by the NIH ECHO program (NIH UG3/UH3OD023271 and UG3/UH3OD023305), NIEHS (1R01ES25169, R01ES016863, P30ES005022, P30ES007033), NHLBI (1R01 HL132338), NCATS (UL1 TR002319), the Urban Child Institute, and the Lisa Stone Pritzker Family Foundation. This three-cohort work could not be conducted without the incredible study staff, data teams, and co-investigators on the three cohorts and PATHWAYS award team, and we are grateful for their efforts as well as the generous contributions of participating women and children over the past decade. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This manuscript has been reviewed by PATHWAYS for scientific content and consistency of data interpretation with previous PATHWAYS publications. Publisher Copyright: {\textcopyright} 2022, The Author(s).",

year = "2023",

month = apr,

doi = "10.1007/s10802-022-01002-3",

language = "English (US)",

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AU - Noroña-Zhou, Amanda

AU - Coccia, Michael

AU - Sullivan, Alexis

AU - O’Connor, Thomas G.

AU - Collett, Brent R.

AU - Derefinko, Karen

AU - Renner, Lynette M.

AU - Loftus, Christine T.

AU - Roubinov, Danielle

AU - Carroll, Kecia N.

AU - Nguyen, Ruby H.N.

AU - Karr, Catherine J.

AU - Sathyanarayana, Sheela

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AU - LeWinn, Kaja Z.

AU - Bush, Nicole R.

N1 - Funding Information: This study was supported by the NIH ECHO program (NIH UG3/UH3OD023271 and UG3/UH3OD023305), NIEHS (1R01ES25169, R01ES016863, P30ES005022, P30ES007033), NHLBI (1R01 HL132338), NCATS (UL1 TR002319), the Urban Child Institute, and the Lisa Stone Pritzker Family Foundation. This three-cohort work could not be conducted without the incredible study staff, data teams, and co-investigators on the three cohorts and PATHWAYS award team, and we are grateful for their efforts as well as the generous contributions of participating women and children over the past decade. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. This manuscript has been reviewed by PATHWAYS for scientific content and consistency of data interpretation with previous PATHWAYS publications. Publisher Copyright: © 2022, The Author(s).

PY - 2023/4

Y1 - 2023/4

N2 - Women’s social experiences can have long-term implications for their offspring’s health, but little is known about the potential independent contributions of multiple periods of stress exposures over time. This study examined associations of maternal exposure to adversity in childhood and pregnancy with children’s anxiety and depression symptoms in a large, sociodemographically diverse sample. Participants were 1389 mother-child dyads (child age M = 8.83 years; SD = 0.66; 42% Black, 42% White; 6% Hispanic) in the ECHO-PATHWAYS Consortium’s three U.S. pregnancy cohorts. Women reported their exposure to childhood traumatic events (CTE) and pregnancy stressful life events (PSLE). Children self-reported on their symptoms of anxiety and depression at age 8–9 years. Regression analyses estimated associations between maternal stressors and children’s internalizing problems, adjusting for confounders, and examined child sex as a modifier. Exploratory interaction analyses examined whether geospatially-linked postnatal neighborhood quality buffered effects. In adjusted models, PSLE counts positively predicted levels of children’s anxiety and depression symptoms ([ßAnxiety=0.08, 95%CI [0.02, 0.13]; ßDepression=0.09, 95%CI [0.03, 0.14]); no significant associations were observed with CTE. Each additional PSLE increased odds of clinically significant anxiety symptoms by 9% (95%CI [0.02, 0.17]). Neither sex nor neighborhood quality moderated relations. Maternal stressors during pregnancy appear to have associations with middle childhood anxiety and depression across diverse sociodemographic contexts, whereas maternal history of childhood adversity may not. Effects appear comparable for boys and girls. Policies and programs addressing prevention of childhood internalizing symptoms may benefit from considering prenatal origins and the potential two-generation impact of pregnancy stress prevention and intervention.

AB - Women’s social experiences can have long-term implications for their offspring’s health, but little is known about the potential independent contributions of multiple periods of stress exposures over time. This study examined associations of maternal exposure to adversity in childhood and pregnancy with children’s anxiety and depression symptoms in a large, sociodemographically diverse sample. Participants were 1389 mother-child dyads (child age M = 8.83 years; SD = 0.66; 42% Black, 42% White; 6% Hispanic) in the ECHO-PATHWAYS Consortium’s three U.S. pregnancy cohorts. Women reported their exposure to childhood traumatic events (CTE) and pregnancy stressful life events (PSLE). Children self-reported on their symptoms of anxiety and depression at age 8–9 years. Regression analyses estimated associations between maternal stressors and children’s internalizing problems, adjusting for confounders, and examined child sex as a modifier. Exploratory interaction analyses examined whether geospatially-linked postnatal neighborhood quality buffered effects. In adjusted models, PSLE counts positively predicted levels of children’s anxiety and depression symptoms ([ßAnxiety=0.08, 95%CI [0.02, 0.13]; ßDepression=0.09, 95%CI [0.03, 0.14]); no significant associations were observed with CTE. Each additional PSLE increased odds of clinically significant anxiety symptoms by 9% (95%CI [0.02, 0.17]). Neither sex nor neighborhood quality moderated relations. Maternal stressors during pregnancy appear to have associations with middle childhood anxiety and depression across diverse sociodemographic contexts, whereas maternal history of childhood adversity may not. Effects appear comparable for boys and girls. Policies and programs addressing prevention of childhood internalizing symptoms may benefit from considering prenatal origins and the potential two-generation impact of pregnancy stress prevention and intervention.

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KW - Child depression

KW - Childhood trauma

KW - Intergenerational transmission

KW - Pregnancy stress

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A Multi-Cohort Examination of the Independent Contributions of Maternal Childhood Adversity and Pregnancy Stressors to the Prediction of Children’s Anxiety and Depression

Abstract

Bibliographical note

Keywords

PubMed: MeSH publication types

UN SDGs

Publisher link

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