A mouse gene encoding a novel member of the WD family of proteins is highly conserved and predominantly expressed in the testis (Wdr13)

Amritha Suresh, Vanya Shah, Deepa Selvi Rani, Bhupendra N. Singh, Gogineni Umaprasad, Subbaya Subramanian, Satish Kumar, Lalji Singh

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Wdr13, a novel member of the WD family of proteins and the mouse homolog of WDR13 is localized to the locus XA1. 1 and is predominantly expressed in the testis. The expression begins at the early stages of gonadal development and is maintained throughout the adult life with a pre-dominant expression in the germ cells of adult testis. RNA in situ hybridization on the testis and brain sections indicated a cytoplasmic expression of the transcript. The alternatively spliced transcripts of the gene are generated by different methods and showed a differential pattern of expression, suggesting functional diversity. The expression of the gene in the unfertilized egg and in the neural stem cells indicated the functional significance of the gene from the early stages of development. The nuclear localization of the mouse WDR13 protein suggested a regulatory function. Evolutionary analysis of the gene indicated an extensive functional conservation across diverse species. Comparison of the genomic organization of the different homologs revealed a varied organization in the invertebrate homolog and the retention of the functionally significant introns in the same.

Original languageEnglish (US)
Pages (from-to)299-310
Number of pages12
JournalMolecular Reproduction and Development
Volume72
Issue number3
DOIs
StatePublished - Nov 1 2005
Externally publishedYes

Keywords

  • Alternative splicing
  • Germ cells
  • Testis
  • WD family of proteins
  • Wdr13

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