A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation

Tuan M. Tran, Rajan Guha, Silvia Portugal, Jeff Skinner, Aissata Ongoiba, Jyoti Bhardwaj, Marcus Jones, Jacqueline Moebius, Pratap Venepally, Safiatou Doumbo, Elizabeth A. DeRiso, Shanping Li, Kamalakannan Vijayan, Sarah L. Anzick, Geoffrey T. Hart, Elise M. O'Connell, Ogobara K. Doumbo, Alexis Kaushansky, Galit Alter, Phillip L. FelgnerHernan Lorenzi, Kassoum Kayentao, Boubacar Traore, Ewen F. Kirkness, Peter D. Crompton

Research output: Contribution to journalArticle

6 Scopus citations

Abstract

The mechanisms that protect from febrile malaria remain unclear. Tran et al. applied a systems-based approach to a longitudinal pediatric study to identify immune signatures that associate with control of malaria fever and parasitemia, revealing that p53 upregulation in monocytes attenuates malaria-induced inflammation and predicts protection from fever.

Original languageEnglish (US)
Pages (from-to)750-765.e10
JournalImmunity
Volume51
Issue number4
DOIs
StatePublished - Oct 15 2019

Keywords

  • Plasmodium falciparum
  • RNA sequencing
  • RNA-seq
  • antibody profiling
  • flow cytometry
  • malaria
  • malaria immunity
  • prospective cohort study
  • systems biology
  • systems immunology
  • transcriptomics

PubMed: MeSH publication types

  • Journal Article
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

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  • Cite this

    Tran, T. M., Guha, R., Portugal, S., Skinner, J., Ongoiba, A., Bhardwaj, J., Jones, M., Moebius, J., Venepally, P., Doumbo, S., DeRiso, E. A., Li, S., Vijayan, K., Anzick, S. L., Hart, G. T., O'Connell, E. M., Doumbo, O. K., Kaushansky, A., Alter, G., ... Crompton, P. D. (2019). A Molecular Signature in Blood Reveals a Role for p53 in Regulating Malaria-Induced Inflammation. Immunity, 51(4), 750-765.e10. https://doi.org/10.1016/j.immuni.2019.08.009