A modular phosphate tether-mediated divergent strategy to complex polyols

Paul R. Hanson, Susanthi Jayasinghe, Soma Maitra, Cornelius N. Ndi, Rambabu Chegondi

Research output: Contribution to journalArticle

7 Scopus citations

Abstract

An efficient and divergent synthesis of polyol subunits utilizing a phosphate tether-mediated, one-pot, sequential RCM/CM/reduction process is reported. A modular, 3-component coupling strategy has been developed, in which, simple "order of addition" of a pair of olefinic-alcohol components to a pseudo-C2 -symmetric phosphoryl chloride, coupled with the RCM/CM/reduction protocol, yields five polyol fragments. Each of the product polyols bears a central 1,3-anti-diol subunit with differential olefinic geometries at the periphery.

Original languageEnglish (US)
Pages (from-to)2332-2337
Number of pages6
JournalBeilstein Journal of Organic Chemistry
Volume10
DOIs
StatePublished - Oct 7 2014
Externally publishedYes

Keywords

  • One-pot
  • Organophosphorus
  • Phosphate-tether
  • Polyol
  • Sequential processes
  • Stereodivergent

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