TY - JOUR
T1 - A model to test the potency of inhalation anaesthetics
AU - Mckenzie, J. Douglas
AU - Calow, Peter
AU - Nimmo, Walter S.
PY - 1989/10
Y1 - 1989/10
N2 - The water flea Daphnia magna was studied as a potential model of the potency of inhalation anaesthetics in humans. Anaesthesia was defined as lack of movement to a noxious stimulus (strong light). Effective concentrations which produced anaesthesia of 50% of the individuals (EC50) for halothane, isoflurane and enflurane were 1.006, 1.156 and 1.415, respectively. Anaesthesia was reversible rapidly. It is suggested that Daphnia should replace vertebrates in early studies of inhalation anaesthetic potency.
AB - The water flea Daphnia magna was studied as a potential model of the potency of inhalation anaesthetics in humans. Anaesthesia was defined as lack of movement to a noxious stimulus (strong light). Effective concentrations which produced anaesthesia of 50% of the individuals (EC50) for halothane, isoflurane and enflurane were 1.006, 1.156 and 1.415, respectively. Anaesthesia was reversible rapidly. It is suggested that Daphnia should replace vertebrates in early studies of inhalation anaesthetic potency.
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U2 - 10.1093/bja/63.4.489
DO - 10.1093/bja/63.4.489
M3 - Article
C2 - 2818927
AN - SCOPUS:0024426145
SN - 0007-0912
VL - 63
SP - 489
EP - 491
JO - British Journal of Anaesthesia
JF - British Journal of Anaesthesia
IS - 4
ER -