A model of painful vaso-occlusive crisis in mice with sickle cell disease

Iryna I. Khasabova, Joseph Juliette, Victoria M. Rogness, Sergey G. Khasabov, Mikhail Y. Golovko, Svetlana A. Golovko, Stacy Kiven, Kalpna Gupta, John D. Belcher, Gregory M. Vercellotti, Virginia S. Seybold, Donald A. Simone

Research output: Contribution to journalArticlepeer-review

2 Scopus citations
Original languageEnglish (US)
Pages (from-to)1826-1830
Number of pages5
JournalBlood
Volume140
Issue number16
DOIs
StatePublished - Oct 20 2022

Bibliographical note

Funding Information:
Conflict-of-interest disclosure: K.G. received honoraria from Tautona Group, Novartis, and CSL Behring; and research grants from Cyclerion, 1910 Genetics, Novartis, Grifols, UCI Foundation, and SCIRE Foundation. The remaining authors declare no competing financial interests.

Funding Information:
This work was supported by National Institutes of Health (NIH), National Cancer Institute Grants CA241627 (D.A.S.) and CA263777 (S.G.K.); NIH, National Heart, Lung, and Blood Institute Grant HL147562 (G.M.V.; J.D.B.); NIH, National Institute of Biomedical Imaging and Bioengineering Grant EB029354 ; the Susan Samueli Scholar Award (K.G.); and NIH, National Heart, Lung, and Blood Institute Grant HL147562 to 03S Supplement to promote diversity (K.G.).

Funding Information:
Liquid chromatography mass spectrometry/mass spectrometry analysis was performed in the University of North Dakota Mass Spectrometry Core Facility supported by the University of North Dakota School of Medicine & Health Sciences Dean's Office. This work was supported by National Institutes of Health (NIH), National Cancer Institute Grants CA241627 (D.A.S.) and CA263777 (S.G.K.); NIH, National Heart, Lung, and Blood Institute Grant HL147562 (G.M.V.; J.D.B.); NIH, National Institute of Biomedical Imaging and Bioengineering Grant EB029354; the Susan Samueli Scholar Award (K.G.); and NIH, National Heart, Lung, and Blood Institute Grant HL147562 to 03S Supplement to promote diversity (K.G.). The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health. Contribution: I.I.K. designed the concept and performed the biochemical and behavioral experiments, analyzed and interpreted data, and wrote the manuscript; J.J. performed behavioral experiments and read the manuscript; V.M.R. performed behavioral experiments and read the manuscript; S.G.K. performed measures of SpO2, core temperature, and heart rate, and edited the manuscript; M.Y.G. performed the mass spectrometric assay and associated data analysis; S.A.G. performed mass spectrometric assay; S.K. bred and phenotyped sickle and control mice and performed quality control; K.G. designed the concept and experimental design, production, and validation of mouse models and editing; J.D.B. performed stasis measurements, contributed to interpretation of data, and read the manuscript; G.M.V. performed stasis measurements, contributed to interpretation of data, and read the manuscript; V.S.S. contributed to the design of experiments, interpretation of data, and writing of the manuscript; and D.A.S. contributed to the design of experiments, interpretation of data, and writing of the manuscript.

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