A model for mercuric ion reduction in recombinant Escherichia coli

George P. Philippidis, Janet L. Schottel, Wei‐Shou ‐S Hu

Research output: Contribution to journalArticlepeer-review

9 Scopus citations


Plasmid‐encoded mercuric reduction involves transfer of Hg2+ across the cellular envelope and reduction to Hg0 by the cytoplasmic mercuric reductase using NADPH. A mathematical model was developed for the binding and transfer of Hg2+ by transport proteins and the subsequent reduction of Hg2+. The values of the model parameters were determined using experimental data. The derived rate expressions were similar to the previously experimentally determined ones. The model predicted that a differential amplification of the transport protein relative to mercuric reductase expression levels may enhance the Hg2+ reduction rate in whole cells.

Original languageEnglish (US)
Pages (from-to)47-54
Number of pages8
JournalBiotechnology and bioengineering
Issue number1
StatePublished - Jan 5 1991


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