A Model for Assay Precision

Douglas M. Hawkins

Research output: Contribution to journalArticlepeer-review

2 Scopus citations


Instructions for use of clinical chemical assays and other instruments commonly include figures for the precision at different levels of the measurand. Frequently neither the variance nor the coefficient of variation (CV) of the measure is constant across the range of measurand values, making such tables difficult to summarize or use. A more flexible variance model fills in the gap between the constant variance and constant CV models, leading to compact summaries of these precision tables and allowing interpolation to levels not included in the study. Likelihood ratio tests show when the more flexible model is needed.

Original languageEnglish (US)
Pages (from-to)263-269
Number of pages7
JournalStatistics in Biopharmaceutical Research
Issue number3
StatePublished - Jul 2014


  • Instructions for use
  • Measurement precision
  • Variance components


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