A model for a hydrogel-enzyme chemomechanical oscillator

Anish P. Dhanarajan, Jon Urban, Ronald A. Siegel

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Scopus citations

Abstract

A glucose-fueled hydrogel/enzyme construct, which may be useful for the autonomous, rhythmic delivery of peptides such as gonadotropin releasing hormone (GnRH), is under investigation. In the present work, an illustrative mathematical model of this system is presented. The model combines aspects of the physical chemistry of hydrophobic polyelectrolyte hydrogels and of chemical kinetics. With this model we explore factors affecting the system's capacity to oscillate, and how certain characteristics of the oscillations are affected by design parameters.

Original languageEnglish (US)
Title of host publicationNonlinear Dynamics in Polymeric Systems
EditorsJohn Pojman, Qui Tran-Cong-Miyata
Pages44-57
Number of pages14
StatePublished - Dec 1 2004

Publication series

NameACS Symposium Series
Volume869
ISSN (Print)0097-6156

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