A microfludic platform to probe the role of pericellular matrix in metastatic extravasation and invasion of breast cancer epithelial cells

Marie Elena Brett, Heather E. Bomberger, Geneva R. Doak, Matthew A. Price, James B. McCarthy, David K. Wood

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

A major barrier to studying the factors that influence the later stages of metastasis including extravasation and invasion of the metastatic site, is the lack of appropriate model systems that allow the quantification of metastatic progression in real time. To investigate the later stages of metastasis, we have developed a novel microfluidic platform that allows us to directly quantify the effect of individual factors on metastatic progression, specifically, the hyaluronan rich pericellular coat, known to promote tumor growth and metastasis. Using this model system, the influence of this coat on cancer cell adhesion, transmigration, and invasion was measured.

Original languageEnglish (US)
Title of host publication21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PublisherChemical and Biological Microsystems Society
Pages1477-1478
Number of pages2
ISBN (Electronic)9780692941836
StatePublished - Jan 1 2020
Event21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States
Duration: Oct 22 2017Oct 26 2017

Publication series

Name21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017

Conference

Conference21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
CountryUnited States
CitySavannah
Period10/22/1710/26/17

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Keywords

  • Extravasation
  • Hyaluronan
  • Metastasis
  • Pericellular coat

Cite this

Brett, M. E., Bomberger, H. E., Doak, G. R., Price, M. A., McCarthy, J. B., & Wood, D. K. (2020). A microfludic platform to probe the role of pericellular matrix in metastatic extravasation and invasion of breast cancer epithelial cells. In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 1477-1478). (21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017). Chemical and Biological Microsystems Society.