Abstract
A major barrier to studying the factors that influence the later stages of metastasis including extravasation and invasion of the metastatic site, is the lack of appropriate model systems that allow the quantification of metastatic progression in real time. To investigate the later stages of metastasis, we have developed a novel microfluidic platform that allows us to directly quantify the effect of individual factors on metastatic progression, specifically, the hyaluronan rich pericellular coat, known to promote tumor growth and metastasis. Using this model system, the influence of this coat on cancer cell adhesion, transmigration, and invasion was measured.
Original language | English (US) |
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Title of host publication | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
Publisher | Chemical and Biological Microsystems Society |
Pages | 1477-1478 |
Number of pages | 2 |
ISBN (Electronic) | 9780692941836 |
State | Published - Jan 1 2020 |
Event | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 - Savannah, United States Duration: Oct 22 2017 → Oct 26 2017 |
Publication series
Name | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
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Conference
Conference | 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 |
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Country/Territory | United States |
City | Savannah |
Period | 10/22/17 → 10/26/17 |
Bibliographical note
Funding Information:This work was funded by NIH Grant CA205455.
Publisher Copyright:
© 17CBMS-0001.
Keywords
- Extravasation
- Hyaluronan
- Metastasis
- Pericellular coat