TY - JOUR

T1 - A mathematical model for carbon dioxide exchange during mechanical ventilation with Tracheal Gas Insufflation (TGI)

AU - Crooke, P. S.

AU - Hota, S.

AU - Marini, J. J.

AU - Hotchkiss, J. R.

PY - 1999/3

Y1 - 1999/3

N2 - A mathematical model is presented to study the effect of Tracheal Gas Insufflation (TGI) on the alveolar ventilation during passive, mechanical ventilation. Equations are derive that relate the physiologic dead space and alveolar ventilation to the physiologic parameters of the patient (compliance, inspiratory and expiratory resistances, anatomical dead space, cardiac output, and shunting), the ventilator settings (frequency, inspiratory time fraction, and pressure waveform), and the catheter settings (flow rate and flow duration). It is shown that optimal alveolar ventilation exists for certain frequencies of ventilation and these frequencies are dependent on the catheter flow.

AB - A mathematical model is presented to study the effect of Tracheal Gas Insufflation (TGI) on the alveolar ventilation during passive, mechanical ventilation. Equations are derive that relate the physiologic dead space and alveolar ventilation to the physiologic parameters of the patient (compliance, inspiratory and expiratory resistances, anatomical dead space, cardiac output, and shunting), the ventilator settings (frequency, inspiratory time fraction, and pressure waveform), and the catheter settings (flow rate and flow duration). It is shown that optimal alveolar ventilation exists for certain frequencies of ventilation and these frequencies are dependent on the catheter flow.

KW - Alveolar ventilation

KW - Carbon dioxide exchange

KW - Mechanical ventilation

KW - Shunt

KW - Tracheal gas insufflation

KW - Two-compartment model

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U2 - 10.1016/S0895-7177(99)00054-0

DO - 10.1016/S0895-7177(99)00054-0

M3 - Article

AN - SCOPUS:0033103690

SN - 0895-7177

VL - 29

SP - 45

EP - 61

JO - Mathematical and Computer Modelling

JF - Mathematical and Computer Modelling

IS - 6

ER -