True density is an important physical property of powdered materials, especially in the context of powder compaction. Currently available methods for true density determination either require a significant amount of materials or are laborious. Hence, a material-sparing and efficient method for true density determination is of value. In this work, we detail a simplified buoyancy-based method capable of fast determination of true density with accuracy comparable to helium pycnometry. This miniaturized method only uses a few milligrams of a powder with data collection process expedited by centrifugation in a laboratory centrifuge. This method can be easily adapted in a laboratory since determination of true density only requires a balance, a micropipette, a laboratory centrifuge, and standard stock liquids of low and high densities. Hence, it is a useful addition to the materials characterization tool kit critical for pharmaceutical formulation development.
|Original language||English (US)|
|Journal||International journal of pharmaceutics|
|State||Published - Mar 25 2023|
Bibliographical noteFunding Information:
Funding from the National Science Foundation through grant number IIP- 1919037 is gratefully acknowledged for partially supporting G.V. Assistance from Carter Supple for data collection is also appreciated.
© 2023 Elsevier B.V.
- True density